Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.
Kang Liang,Raffaele Ricco,Cara M. Doherty,Mark J. Styles,Stephen Bell,Nigel Kirby,Stephen T. Mudie,David N. Haylock,Anita J. Hill,Christian J. Doonan,Paolo Falcaro +10 more
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TLDR
It is shown that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules.Abstract:
Robust biomacromolecules could be used for a wide range of biotechnological applications. Here the authors report a biomimetic mineralization process, in which biomolecules are encapsulated within metal-organic frameworks, and their stability is subsequently increased without significant bioactivity loss.read more
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Recyclable β-Glucosidase by One-Pot Encapsulation with Cu-MOFs for Enhanced Hydrolysis of Cellulose to Glucose
TL;DR: In this article, the β-glucosidase (β-G) was encapsulated into the Cu-MOF due to its acidic stability, using a coprecipitation approach.
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Thiazole-Linked Covalent Organic Framework Promoting Fast Two-Electron Transfer for Lithium-Organic Batteries
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In vivo behavior of MIL-100 nanoparticles at early times after intravenous administration.
Teresa Simón-Yarza,Tarek Baati,Fadwa Neffati,Leila Njim,Patrick Couvreur,Christian Serre,Ruxandra Gref,M. Fadhel Najjar,Abdelfattah Zakhama,Patricia Horcajada,Patricia Horcajada +10 more
TL;DR: The pharmacokinetic profile suggested that the nanoparticles act as a depot in the blood stream during the first hours before being cleared, and histological studies demonstrated the absence of morphological alterations due to the presence of the particles in these organs.
Journal ArticleDOI
Size-Controlled Synthesis of Drug-Loaded Zeolitic Imidazolate Framework in Aqueous Solution and Size Effect on Their Cancer Theranostics in Vivo
TL;DR: A one-pot, rapid, and completely aqueous approach that can precisely tune the size of drug-loaded MOF at room temperature is reported that helps to find the optimal size of MOF as a drug carrier and opens new possibilities to construct multifunctional delivery systems for cancer theranostics.
Journal ArticleDOI
Metal-Organic Framework as a Protective Coating for Biodiagnostic Chips.
Congzhou Wang,Sirimuvva Tadepalli,Jingyi Luan,Keng-Ku Liu,Jeremiah J. Morrissey,Evan D. Kharasch,Rajesh R. Naik,Srikanth Singamaneni +7 more
TL;DR: The biofunctionality of the ZIF-8-protected biochip can be restored by a simple water-rinsing step, making it highly convenient for use in point-of-care and resource-limited settings.
References
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Journal ArticleDOI
The Chemistry and Applications of Metal-Organic Frameworks
Hiroyasu Furukawa,Hiroyasu Furukawa,Kyle E. Cordova,Kyle E. Cordova,Michael O'Keeffe,Michael O'Keeffe,Omar M. Yaghi,Omar M. Yaghi,Omar M. Yaghi +8 more
TL;DR: Metal-organic frameworks are porous materials that have potential for applications such as gas storage and separation, as well as catalysis, and methods are being developed for making nanocrystals and supercrystals of MOFs for their incorporation into devices.
Journal ArticleDOI
Reticular synthesis and the design of new materials
Omar M. Yaghi,Michael O'Keeffe,Nathan W. Ockwig,Hee K. Chae,Hee K. Chae,Mohamed Eddaoudi,Jaheon Kim +6 more
TL;DR: This work has shown that highly porous frameworks held together by strong metal–oxygen–carbon bonds and with exceptionally large surface area and capacity for gas storage have been prepared and their pore metrics systematically varied and functionalized.
Journal ArticleDOI
Exceptional chemical and thermal stability of zeolitic imidazolate frameworks
Kyo Sung Park,Zheng Ni,Adrien P. Côté,Jae Yong Choi,Rudan Huang,Fernando J. Uribe-Romo,Hee K. Chae,Michael O'Keeffe,Omar M. Yaghi +8 more
TL;DR: Study of the gas adsorption and thermal and chemical stability of two prototypical members, ZIF-8 and -11, demonstrated their permanent porosity, high thermal stability, and remarkable chemical resistance to boiling alkaline water and organic solvents.
Book ChapterDOI
The assay of catalases and peroxidases.
Britton Chance,A.C. Maehly +1 more
TL;DR: Two methods are described for the catalase assay by disappearance of peroxide are: ultraviolet spectrophotometry and permanganate titration and indirect measurements of the decrease of light absorption caused by the decomposition of hydrogen peroxide byCatalase.
Journal ArticleDOI
Metal-organic frameworks in biomedicine.
Patricia Horcajada,Ruxandra Gref,Tarek Baati,Phoebe K. Allan,Guillaume Maurin,Patrick Couvreur,Gérard Férey,Russell E. Morris,Christian Serre +8 more
TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.