Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.
Kang Liang,Raffaele Ricco,Cara M. Doherty,Mark J. Styles,Stephen Bell,Nigel Kirby,Stephen T. Mudie,David N. Haylock,Anita J. Hill,Christian J. Doonan,Paolo Falcaro +10 more
TLDR
It is shown that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules.Abstract:
Robust biomacromolecules could be used for a wide range of biotechnological applications. Here the authors report a biomimetic mineralization process, in which biomolecules are encapsulated within metal-organic frameworks, and their stability is subsequently increased without significant bioactivity loss.read more
Citations
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Exfoliated Nanosheets of a CuII Coordination Polymer Modulate Enzyme Activity of α-Chymotrypsin.
TL;DR: A 2D coordination polymer derived from 5-azidoisophthalic acid and Cu(NO3 )2 was designed with the aim of modulating the activity of a digestive enzyme α-chymotrypsin and revealed that the inhibition of ChT followed a competitive pathway.
Journal ArticleDOI
Hollow Mesoporous Metal-Organic Framework Microdisks via a Solid Template-Based Approach and Post-Synthetic Wet-Chemical Etching for Protein Loading
Journal ArticleDOI
Stability of ZIF-8 Nanoparticles in Most Common Cell Culture Media
Anna S. Spitsyna,Artem S. Poryvaev,Natalya E. Sannikova,Anastasiya A. Yazikova,Igor A. Kirilyuk,Sergey A. Dobrynin,Olga A. Chinak,Matvey V. Fedin,Olesya A. Krumkacheva +8 more
TL;DR: A quantitative investigation of the ZIF-8 nanoparticle’s stability in most common cell culture media was reported and a strong correlation between the amount of escaped cargo and total concentration of amino acids in the environment was found.
Journal ArticleDOI
De novo synthesis of enzyme-embedded covalent organic frameworks (COFs) using deep eutectic solvent: Pushing the COF limits
TL;DR: In this article , an enzyme embedding within imine-based COFs regardless of pore dimensions is presented by pre-functionalizing the enzyme with COF aldehyde precursor and facilitating "armor-like" COF exoskeleton formation from the enzyme surface via condensation of COF and amine precursors at ambient conditions using choline chloride/urea deep eutectic solvent as both solvent and catalyst.
Journal ArticleDOI
Efficient delivery of cytosolic proteins by protein-hexahistidine-metal co-assemblies.
Wenjuan Huang,Sijie Zhou,Bojiao Tang,Hongyan Xu,Xiaoxiao Wu,Na Li,Xingjie Zan,Xingjie Zan,Wujun Geng +8 more
TL;DR: Based on the coordinative interaction between His6 and metal ions, various proteins were encapsulated in situ into nanosized and positively charged protein encapsulation particles (Protein@HmA) through a co-assembly process with a high loading capacity and loading efficiency as mentioned in this paper.
References
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Journal ArticleDOI
The Chemistry and Applications of Metal-Organic Frameworks
Hiroyasu Furukawa,Hiroyasu Furukawa,Kyle E. Cordova,Kyle E. Cordova,Michael O'Keeffe,Michael O'Keeffe,Omar M. Yaghi,Omar M. Yaghi,Omar M. Yaghi +8 more
TL;DR: Metal-organic frameworks are porous materials that have potential for applications such as gas storage and separation, as well as catalysis, and methods are being developed for making nanocrystals and supercrystals of MOFs for their incorporation into devices.
Journal ArticleDOI
Reticular synthesis and the design of new materials
Omar M. Yaghi,Michael O'Keeffe,Nathan W. Ockwig,Hee K. Chae,Hee K. Chae,Mohamed Eddaoudi,Jaheon Kim +6 more
TL;DR: This work has shown that highly porous frameworks held together by strong metal–oxygen–carbon bonds and with exceptionally large surface area and capacity for gas storage have been prepared and their pore metrics systematically varied and functionalized.
Journal ArticleDOI
Exceptional chemical and thermal stability of zeolitic imidazolate frameworks
Kyo Sung Park,Zheng Ni,Adrien P. Côté,Jae Yong Choi,Rudan Huang,Fernando J. Uribe-Romo,Hee K. Chae,Michael O'Keeffe,Omar M. Yaghi +8 more
TL;DR: Study of the gas adsorption and thermal and chemical stability of two prototypical members, ZIF-8 and -11, demonstrated their permanent porosity, high thermal stability, and remarkable chemical resistance to boiling alkaline water and organic solvents.
Book ChapterDOI
The assay of catalases and peroxidases.
Britton Chance,A.C. Maehly +1 more
TL;DR: Two methods are described for the catalase assay by disappearance of peroxide are: ultraviolet spectrophotometry and permanganate titration and indirect measurements of the decrease of light absorption caused by the decomposition of hydrogen peroxide byCatalase.
Journal ArticleDOI
Metal-organic frameworks in biomedicine.
Patricia Horcajada,Ruxandra Gref,Tarek Baati,Phoebe K. Allan,Guillaume Maurin,Patrick Couvreur,Gérard Férey,Russell E. Morris,Christian Serre +8 more
TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.