Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.
Kang Liang,Raffaele Ricco,Cara M. Doherty,Mark J. Styles,Stephen Bell,Nigel Kirby,Stephen T. Mudie,David N. Haylock,Anita J. Hill,Christian J. Doonan,Paolo Falcaro +10 more
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TLDR
It is shown that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules.Abstract:
Robust biomacromolecules could be used for a wide range of biotechnological applications. Here the authors report a biomimetic mineralization process, in which biomolecules are encapsulated within metal-organic frameworks, and their stability is subsequently increased without significant bioactivity loss.read more
Citations
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Nanoscale Metal–Organic Framework Co-delivers TLR-7 Agonists and Anti-CD47 Antibodies to Modulate Macrophages and Orchestrate Cancer Immunotherapy
TL;DR: surface modification of a Hf-DBP nMOF is reported for the co-delivery of a hydrophobic small-molecule toll-like receptor 7 agonist, imiquimod (IMD), and a Hydrophilic macromolecule, anti-CD47 antibody (αCD47), for macrophage modulation and reversal of immunosuppression in tumors.
Journal ArticleDOI
Exploration of MOF nanoparticle sizes using various physical characterization methods – is what you measure what you get?
Patrick Hirschle,Tobias Preiß,Florian Auras,André Pick,Johannes Völkner,Daniel Valdeperez,Gregor Witte,Wolfgang J. Parak,Joachim O. Rädler,Stefan Wuttke +9 more
TL;DR: In this article, the size of metal-organic framework (MOF) nanoparticles (Zr-fum MOF NPs) was determined using various common characterization methods, such as powder X-ray diffraction (PXRD), atomic force microscopy (AFM), scanning electron microscopy and TEM.
Journal ArticleDOI
Multifunctional metal–organic frameworks-based biocatalytic platforms: recent developments and future prospects
TL;DR: In this paper, metal-organic frameworks (MOFs) have received accelerating research attention as a versatile carrier and promising bio-immobilization support materials for enzyme immobilization, such as surface area, high porosity, tunable topography, crystallinity, electronic and optical properties, thermal/chemical stability and multiple affinities.
Journal ArticleDOI
Silver Nanoclusters Encapsulated into Metal–Organic Frameworks with Enhanced Fluorescence and Specific Ion Accumulation toward the Microdot Array-Based Fluorimetric Analysis of Copper in Blood
Chuan Fan,Xiaoxia Lv,Fengjuan Liu,Luping Feng,Min Liu,Yuanyuan Cai,Huan Liu,Jingyi Wang,Yanli Yang,Hua Wang +9 more
TL;DR: It was discovered that the developed fluorimetric strategy could ensure the high-throughput analysis of Cu2+ ions in wide pH range, and especially some harsh and high-salt media.
Journal ArticleDOI
Encapsulation of aggregated gold nanoclusters in a metal–organic framework for real-time monitoring of drug release
Fangfang Cao,Fangfang Cao,Enguo Ju,Chaoqun Liu,Wei Li,Yan Zhang,Kai Dong,Zhen Liu,Jinsong Ren,Xiaogang Qu +9 more
TL;DR: In this paper, aggregated gold nanoclusters (aAuNCs) were confined in a metal-organic framework (MOF) to maintain their aggregation, restrict the rotation of their ligands, and further improve their quantum yield.
References
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Hiroyasu Furukawa,Hiroyasu Furukawa,Kyle E. Cordova,Kyle E. Cordova,Michael O'Keeffe,Michael O'Keeffe,Omar M. Yaghi,Omar M. Yaghi,Omar M. Yaghi +8 more
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Omar M. Yaghi,Michael O'Keeffe,Nathan W. Ockwig,Hee K. Chae,Hee K. Chae,Mohamed Eddaoudi,Jaheon Kim +6 more
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Kyo Sung Park,Zheng Ni,Adrien P. Côté,Jae Yong Choi,Rudan Huang,Fernando J. Uribe-Romo,Hee K. Chae,Michael O'Keeffe,Omar M. Yaghi +8 more
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The assay of catalases and peroxidases.
Britton Chance,A.C. Maehly +1 more
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Patricia Horcajada,Ruxandra Gref,Tarek Baati,Phoebe K. Allan,Guillaume Maurin,Patrick Couvreur,Gérard Férey,Russell E. Morris,Christian Serre +8 more
TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.