Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.
Kang Liang,Raffaele Ricco,Cara M. Doherty,Mark J. Styles,Stephen Bell,Nigel Kirby,Stephen T. Mudie,David N. Haylock,Anita J. Hill,Christian J. Doonan,Paolo Falcaro +10 more
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TLDR
It is shown that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules.Abstract:
Robust biomacromolecules could be used for a wide range of biotechnological applications. Here the authors report a biomimetic mineralization process, in which biomolecules are encapsulated within metal-organic frameworks, and their stability is subsequently increased without significant bioactivity loss.read more
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Electrostatic Interaction-Induced Formation of Enzyme-on-MOF as Chemo-Biocatalyst for Cascade Reaction with Unexpectedly Acid-Stable Catalytic Performance.
TL;DR: GOx/PCN-222(Fe) exhibits an exceptional acid-stable catalytic performance as evidenced by circular dichroism spectroscopy, where no significant structure change was observed towards acidic solutions with different pH values.
Journal ArticleDOI
Antifungal-Inbuilt Metal–Organic-Frameworks Eradicate Candida albicans Biofilms
Linzhu Su,Yuanfeng Li,Yong Liu,Rujiang Ma,Yang Liu,Fan Huang,Yingli An,Yijin Ren,Henny C. van der Mei,Henk J. Busscher,Linqi Shi +10 more
TL;DR: In a murine model, the design and synthesis of voriconazole‐inbuilt zinc 2‐methylimidazolates frameworks (V‐ZIF) may provide a welcome addition to the antifungal armamentarium currently available for the treatment of fungal biofilms.
Journal ArticleDOI
Biomimic Nanozymes with Tunable Peroxidase-like Activity Based on the Confinement Effect of Metal-Organic Frameworks (MOFs) for Biosensing.
Nuanfei Zhu,Chengbin Liu,Rui Liu,Xiangheng Niu,Dinghui Xiong,Kun Wang,Daqiang Yin,Zhen Zhang +7 more
TL;DR: Satisfactory results highlight that using a ZIF-8 outer layer to encapsulate Hemin@BSA offers a very effective and successful strategy to improve the peroxidase-like activity and the stability of biomimic nanozymes, broadening the potential application of biocatalytic metal-organic frameworks (MOFs).
Journal ArticleDOI
A Flexible Interpenetrated Zirconium-Based Metal-Organic Framework with High Affinity toward Ammonia.
Yuanyuan Zhang,Yuanyuan Zhang,Xuan Zhang,Zhijie Chen,Ken-ichi Otake,Gregory W. Peterson,Yongwei Chen,Xingjie Wang,Louis R. Redfern,Subhadip Goswami,Peng Li,Timur Islamoglu,Bo Wang,Omar K. Farha +13 more
TL;DR: A flexible, interpenetrated Zr-MOF, NU-1401, composed of rare 4-connected Zr6 nodes and tetratopic naphthalenediimide (NDI)-based carboxylate linkers is reported, showing that the distance and overlap angle between the stacked NDI pairs in the entangled structure can be finely tuned and the interactions between NDI and solvent molecules lead to a solvochromism property.
Journal ArticleDOI
Metal-Organic Framework Encapsulating Hemoglobin as a High-Stable and Long-Circulating Oxygen Carriers to Treat Hemorrhagic Shock
TL;DR: ZIF-8@Hb offers a high-stable and long-circulating oxygen carrier platform, which may find wide applications as blood substitute to treat various oxygen-relevent diseases.
References
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The Chemistry and Applications of Metal-Organic Frameworks
Hiroyasu Furukawa,Hiroyasu Furukawa,Kyle E. Cordova,Kyle E. Cordova,Michael O'Keeffe,Michael O'Keeffe,Omar M. Yaghi,Omar M. Yaghi,Omar M. Yaghi +8 more
TL;DR: Metal-organic frameworks are porous materials that have potential for applications such as gas storage and separation, as well as catalysis, and methods are being developed for making nanocrystals and supercrystals of MOFs for their incorporation into devices.
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Reticular synthesis and the design of new materials
Omar M. Yaghi,Michael O'Keeffe,Nathan W. Ockwig,Hee K. Chae,Hee K. Chae,Mohamed Eddaoudi,Jaheon Kim +6 more
TL;DR: This work has shown that highly porous frameworks held together by strong metal–oxygen–carbon bonds and with exceptionally large surface area and capacity for gas storage have been prepared and their pore metrics systematically varied and functionalized.
Journal ArticleDOI
Exceptional chemical and thermal stability of zeolitic imidazolate frameworks
Kyo Sung Park,Zheng Ni,Adrien P. Côté,Jae Yong Choi,Rudan Huang,Fernando J. Uribe-Romo,Hee K. Chae,Michael O'Keeffe,Omar M. Yaghi +8 more
TL;DR: Study of the gas adsorption and thermal and chemical stability of two prototypical members, ZIF-8 and -11, demonstrated their permanent porosity, high thermal stability, and remarkable chemical resistance to boiling alkaline water and organic solvents.
Book ChapterDOI
The assay of catalases and peroxidases.
Britton Chance,A.C. Maehly +1 more
TL;DR: Two methods are described for the catalase assay by disappearance of peroxide are: ultraviolet spectrophotometry and permanganate titration and indirect measurements of the decrease of light absorption caused by the decomposition of hydrogen peroxide byCatalase.
Journal ArticleDOI
Metal-organic frameworks in biomedicine.
Patricia Horcajada,Ruxandra Gref,Tarek Baati,Phoebe K. Allan,Guillaume Maurin,Patrick Couvreur,Gérard Férey,Russell E. Morris,Christian Serre +8 more
TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.