Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules.
Kang Liang,Raffaele Ricco,Cara M. Doherty,Mark J. Styles,Stephen Bell,Nigel Kirby,Stephen T. Mudie,David N. Haylock,Anita J. Hill,Christian J. Doonan,Paolo Falcaro +10 more
TLDR
It is shown that proteins, enzymes and DNA rapidly induce the formation of protective metal-organic framework coatings under physiological conditions by concentrating the framework building blocks and facilitating crystallization around the biomacromolecules.Abstract:
Robust biomacromolecules could be used for a wide range of biotechnological applications. Here the authors report a biomimetic mineralization process, in which biomolecules are encapsulated within metal-organic frameworks, and their stability is subsequently increased without significant bioactivity loss.read more
Citations
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Biomineralized DNA nanospheres by metal organic framework for enhanced chemodynamic therapy
TL;DR: By exploitation of tumor acid-activable cascade reactions for supplying sufficient H2O2, this CDT agent achieves prominent therapeutic efficacy in both in vitro and in vivo assays and provides a promising strategy to develop CDT agents for improved CDT efficacy.
Journal ArticleDOI
Protein-assisted synthesis of nanoscale covalent organic frameworks for phototherapy of cancer
TL;DR: A protein-assisted synthesis method has been proposed for preparing stable covalent organic frameworks (COFs) with both photothermal and photodynamic activity under the excitation of a laser at a single wavelength.
Journal ArticleDOI
Biomineralization-mimetic preparation of robust metal-organic frameworks biocomposites film with high enzyme load for electrochemical biosensing
TL;DR: Inspired by biomineralization, a robust enzyme-metal-organic-frameworks (MOFs) biocomposites were proposed to fabricate ultra-stable modified-electrode for electrochemical biosensing as discussed by the authors.
Journal ArticleDOI
Tailoring metal-organic frameworks-based nanozymes for bacterial theranostics.
TL;DR: In this paper, a review of the design and fabrication of metal-organic frameworks (MOFs) is presented, and the major obstacles and opportunities for further development in research on the interface of nanozymes and MOFs are discussed.
Journal ArticleDOI
The application of biomacromolecules to improve oral absorption by enhanced intestinal permeability: A mini-review
TL;DR: A series of biomacromolecules and the related mechanisms of increasing intestinal permeability for enhanced oral bioavailability are comprehensively classified and elucidated.
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