Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
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Journal ArticleDOI
Cucurbit[7]uril-Mediated Supramolecular Bactericidal Nanoparticles: Their Assembly Process, Controlled Release, and Safe Treatment of Intractable Plant Bacterial Diseases.
Qingtian Ji,De-Kun Hu,Xianfu Mu,Xiaomeng Tian,Li Zhou,Si Yao,Xiao-Hui Wang,Shuzhen Xiang,Hao-Jie Ye,Li-Jun Fan,Pei-Yi Wang +10 more
TL;DR: In this paper , a safe, biocompatible, and stimuli-responsive cucurbit[7]uril-mediated supramolecular bactericidal nanoparticle was fabricated by encapsulating a highly bioactive carbazole-decorated imidazolium salt (A1, EC50 = 0.647 μg/mL against phytopathogen Xanthomonas oryzae pvOryzae) into the host cucurbitsuril (CB[7]), thereby leading to self-assembled topographies from microsheets to nanospheroidal architectures.
Journal ArticleDOI
Structural investigation of the β-cyclodextrin complexes with chiral bicyclic monoterpenes – Influence of the functionality group on the host-guest stoichiometry
TL;DR: In this paper, the crystal structures of β−cyclodextrin with (+)− and (−)-camphors are presented and compared with available data for other complexes with chiral bicyclic monoterpenes (hydrocarbon (+)-fenchene and alcohols).
Book ChapterDOI
Cyclodextrin-based drug-delivery systems
TL;DR: This chapter provides a brief overview of the CDs chemistry, safety profile, and regulatory status, and the use of CDs as novel therapeutically active agents.
Journal ArticleDOI
Utilization of Water-Soluble Aminoethylamino-β-Cyclodextrin in the Pfitzinger Reaction-Catalyzed to the Synthesis of Diversely Functionalized Quinaldine.
TL;DR: This supramolecular catalyst exhibited remarkable catalytic activity with high substrate scope to achieve the synthetic targets in good to excellent yield, 69–92%.
Journal ArticleDOI
DFT study of the per-6-amino-β-cyclodextrin as catalyst in synthesis of 2-aryl-2,3-dihydro-4-quinolones
Yali Wan,Xueye Wang,Na Liu +2 more
TL;DR: Study of the complexes of per-6-ABCD with benzaldehyde and o-aminoacetophenone using density functional theory (DFT) method to propose the donor–acceptor interactions of complex.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
Journal ArticleDOI
Cyclodextrin Drug Carrier Systems.
Journal ArticleDOI
Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.