Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
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Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
TL;DR: This review focuses on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators.
Journal ArticleDOI
Biomedical Applications of Supramolecular Systems Based on Host-Guest Interactions.
Xing Ma,Yanli Zhao +1 more
TL;DR: Host−Guest Supramolecular Chemistry A 1.1.1: Aims to explore the role of “ghostly” particles in the determination of chiral stationary phases and their role in the “spatially modified” states.
Journal ArticleDOI
Hydrogels in a historical perspective: from simple networks to smart materials.
Sytze J. Buwalda,Kristel W. M. Boere,Pieter J. Dijkstra,Jan Feijen,Tina Vermonden,Wim E. Hennink +5 more
TL;DR: A historical overview of the developments in hydrogel research from simple networks to smart materials is provided to overcome several challenges to overcome for clinical translation.
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TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Christopher B. Rodell,Sean P. Arlauckas,Michael F. Cuccarese,Christopher Garris,Ran Li,Maaz S. Ahmed,Rainer H. Kohler,Mikael J. Pittet,Ralph Weissleder +8 more
TL;DR: The ability of rationally engineered drug–nanoparticle combinations to efficiently modulate tumour-associated macrophages for cancer immunotherapy is demonstrated and R848, an agonist of the toll-like receptors TLR7 and TLR8 identified in a morphometric-based screen, is a potent driver of the M1 phenotype in vitro.
References
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Multivalent binding of galactosylated cyclodextrin vesicles to lectin
Antonino Mazzaglia,Damien Forde,Domenico Garozzo,Paola Malvagna,Bart Jan Ravoo,Raphael Darcy +5 more
TL;DR: Amphiphilic β-cyclodextrins with alkylthio chains at the primary-hydroxyl side and galactosylthio-oligo-(ethylene glycol) units at the secondary-oxyl side, which form nanoparticles and vesicles, show multivalent effects in their binding to lectin this paper.
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Preparation of vesicles and nanoparticles of amphiphilic cyclodextrins containing labile disulfide bonds
TL;DR: These compounds were obtained by 1,3-dicyclohexylcarbodiimide-mediated coupling reactions of heptakis(6-amino-6-deoxy)-B-cyclodextrins and disulfide-containing carboxylic acids of increasing hydrophobicity by improving the water solubility of the cyclodextrin molecules.
Book ChapterDOI
Functional Cyclodextrin Polyrotaxanes for Drug Delivery
TL;DR: A supramolecular approach using CD-containing polyrotaxanes is expected to exploit a new paradigm of biomaterials to achieve effective gene delivery and enhance multivalent interaction between ligand-receptor systems.
Journal ArticleDOI
Facile Engineering of Biocompatible Materials with pH‐Modulated Degradability
TL;DR: There is an urgent demand for developing alternative materials that overcome the drawbacks of biodegradable acid-producing polymers, while possessing the desirable sensitivity of synthetic polymers.
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Highly efficient nanomedicines assembled via polymer-drug multiple interactions: Tissue-selective delivery carriers.
TL;DR: This study presents the construction and evaluation of highly efficient nanomedicines via self-assembly directed by multiple non-covalent interactions between carrier polymer and cargo molecules, including hydrophobic, host-guest recognition, hydrogen bonding and electrostatic forces.