Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
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Decoration of β-CD-ZrO on Fe3O4 magnetic nanoparticles as a magnetically, recoverable and reusable catalyst for the synthesis of 2,3-dihydro-1H-perimidines
TL;DR: In this article, a covalent grafting of ZrO to β-CD to prepare an organic-inorganic hybrid material was proposed, which was successfully linked on the surface of Fe3O4 magnetic nanoparticles and characterized by TGA, XRF, XRD, FT-IR and TEM techniques.
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Peptide hydrogels for affinity-controlled release of therapeutic cargo: Current and potential strategies
TL;DR: In this paper, the authors present a peptide-based peptide gel release system and their associated mechanisms for applications in drug delivery. But, this strategy has not been widely implemented in peptidebased hydrogels.
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Selective Autonomous Molecular Transport and Collection by Hydrogel-Embedded Supramolecular Chemical Gradients.
Shiyan Zhang,Chunjie Zhang,Hao Chen,Spencer J. Kieffer,Frank Neubrech,Frank Neubrech,Harald Giessen,Andrew G. Alleyne,Paul V. Braun +8 more
TL;DR: An array of IR resonant metallic nanoantennas tuned to a specific IR absorption band of theanalyte to enhance the IR signal generated by the analyte are used to provide a near real-time read-out of the concentration of the analyzete.
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Accurate Quantification of N-Glycolylneuraminic Acid in Therapeutic Proteins Using Supramolecular Mass Spectrometry
TL;DR: A supramolecular mass spectrometry (MS)-based method using a synthetic host, cucurbit[7]uril (CB[7]), was developed for identifying and quantifying N-glycolylneuraminic acid (Neu5C) in therapeutic glycoproteins, which critically reduces drug efficacy.
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Antibiotic-in-cyclodextrin-in-liposomes: formulation development and interactions with model bacterial membranes
Kalliopi-Kelli A. Vandera,Pietro Picconi,Margarita Valero,Gustavo González-Gaitano,Arcadia Woods,Nur Masirah M. Zain,Kenneth D. Bruce,Luke A. Clifton,Maximilian W. A. Skoda,Khondaker M. Rahman,Richard D. Harvey,Cécile A. Dreiss +11 more
TL;DR: An antibiotic- in-cyclodextrin-in-liposomes (ACL) formulation was developed, which targets both the bacterial OM and IM, and offers promise as a means to breach the Gram-negative cell envelope.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
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Cyclodextrin Drug Carrier Systems.
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Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.