Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
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Host–guest inclusion system of artesunate with β-cyclodextrin and its derivatives: Characterization and antitumor activity
TL;DR: In this paper, a 1:1 stoichiometry host-guest compound between artesunate (ATS) and three cyclodextrins, namely β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HP-β-, β-CD) and sulfobutyl ether-β -cyclodiscrin (SBE-β,CD), were prepared by a suspension method.
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Dual UV- and pH-Responsive Supramolecular Vesicles Mediated by Host–Guest Interactions for Drug Controlled Release
Xiaojin Zhang,Ren-Xi Zhuo +1 more
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Injectable micellar supramolecular hydrogel for delivery of hydrophobic anticancer drugs.
TL;DR: In vitro release study showed that the release behavior of PTX from hydrogel could be modulated by change the α-CD amount in Hydrogel, and such supramolecular hydrogels could enhance the biological activity of encapsulated PTX compared to free PTX, as indicated by in vitro cytotoxicity assay.
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Age-related ocular conditions: Current treatments and role of cyclodextrin-based nanotherapies.
Blanca Lorenzo-Veiga,Carmen Alvarez-Lorenzo,Thorsteinn Loftsson,Hakon H. Sigurdsson,Hakon H. Sigurdsson +4 more
TL;DR: In this paper, the authors discuss emerging therapeutic options based on nanoengineering of cyclodextrin nanocarriers for the treatment of age-related eye disorders, including their pathophysiology, pharmacological options, and feasibility of clinical translation.
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Combination of phase-solubility method and capillary zone electrophoresis to determine binding constants of cyclodextrins with practically water-insoluble compounds
TL;DR: The combined method based on phase‐solubility technique and capillary zone electrophoresis (PS‐CZE) was suggested for the determination of binding (stability) constants of cyclodextrins (CD) complexes with water‐insoluble organic compounds that have no or weak UV chromophores.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
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Cyclodextrin Drug Carrier Systems.
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Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.