Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
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Polypseudorotaxane functionalized magnetic nanoparticles as a dual responsive carrier for roxithromycin delivery.
Yu Ke,Xiaoye Zhang,Caikun Liu,Meng Xiao,Hong Li,Jiachen Fan,Pengcheng Fu,Shuhao Wang,Fei Zan,Gang Wu +9 more
TL;DR: CDMNP-PEG-CD nanocomposites allowed for the localization and fast concentration of hydrophobic drugs, providing a broad potential range of therapeutic applications, including antibacterial therapy and pH-responsive drug release behaviors.
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Bypassing P-glycoprotein mediated efflux of afatinib by cyclodextrin complexation – Evaluation of intestinal absorption and anti-cancer activity
Vineela Parvathaneni,Rasha Elbatanony,Rasha Elbatanony,Snehal K. Shukla,Nishant S. Kulkarni,Dipti D. Kanabar,Gautam Chauhan,Seyoum Ayehunie,Zhe-Sheng Chen,Aaron Muth,Vivek Gupta +10 more
TL;DR: Results demonstrated that cyclodextrin complexation significantly increased the transport of afatinib across the gut membrane while also reducing its efflux ratio, indicating its vital role in P-gp efflux modulation.
Journal ArticleDOI
Construction of Crowning β-cyclodextrin with Temperature Response and Efficient Properties of Host–Guest Inclusion
Dongmei Zhang,Cheng Yang,Ziru Niu,Changhao Wang,Somnath Mukherjee,Dan Wang,Xi Li,Ruiqi Liu,Jin Gao,Ya-Shao Chen +9 more
TL;DR: The crowning β- cyclodextrins formed by intramolecular hydrogen bonding interaction has greatly prolonged the cavity depth of β-cyclodextrin, and therefore further efficiently improved the inclusion proportion to complex drug molecule (vitamin E).
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Preparation and characterization of a imipramine-ß-cyclodextrin inclusion complex
TL;DR: In this paper, the formation of supramolecular host-guest inclusion complex of imipramine with the nano-hydrophobic cavity of s-cyclodextrin was prepared by physical mixing and coprecipitation.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
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Cyclodextrin Drug Carrier Systems.
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Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.