Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
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Journal ArticleDOI
Spectral, thermal, and molecular modeling studies on the encapsulation of selected sulfonamide drugs in β-cyclodextrin nano-cavity.
TL;DR: Using semi-empirical quantum chemistry methods at PM3 theoretical level, inclusion complexes' structures as well as energetic and thermodynamic parameters of encapsulation were elucidated and revealed that the encapsulation is favorably energetic and enthalpic in nature with the inclusion of the aniline moiety through the wide rim side of β-CD nano-cavity.
Journal ArticleDOI
Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal in vivo imaging
Sung Wan Kim,Gyeongwon Yun,Suman Khan,Jinhwan Kim,James Brooke Murray,Yeong Mi Lee,Won Jong Kim,Gyudong Lee,Sungjee Kim,Dinesh K. Shetty,Joo Hyun Kang,Jung Young Kim,Kyeng Min Park,Kimoon Kim +13 more
TL;DR: The potential of non-covalently modified nanomaterials in real world in vivo systems is demonstrated by taking advantage of the strong and robust host–guest interaction between CB and spermidine under in vivo conditions.
Journal ArticleDOI
Application of cyclodextrins in cancer treatment
Neng Qiu,Xuebing Li,Junda Liu +2 more
TL;DR: CD modified delivery system for anticancer drugs are shown to provide improved encapsulation, prolonged release, increased therapeutic efficacy and reduced toxicity, and there is a prerequisite to exploit the utility of CDs and CDs-based carriers using in vivo tumor models for pharmacokinetics, pharmacodynamics and toxicity studies to validate their safety and efficacy.
Journal ArticleDOI
Citrate modified β-cyclodextrin functionalized magnetite nanoparticles: a biocompatible platform for hydrophobic drug delivery
Kunnoth N. Jayaprabha,P. A. Joy +1 more
TL;DR: The water-dispersible, CIT modified β-CD functionalized magnetite nanofluid is an efficient carrier for water insoluble curcumin, and can be used for magnetic drug targeting/delivery as well as for contrast enhancement in MRI due to the superparamagnetic magnetite core.
Journal ArticleDOI
Shell-sheddable, pH-sensitive supramolecular nanoparticles based on ortho ester-modified cyclodextrin and adamantyl PEG.
TL;DR: A new type of pH-sensitive supramolecular aggregates which possess a programmable character of sequential dePEGylation and degradation and are capable of being surface-functionalized via dynamic host-guest interaction are reported.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
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Cyclodextrin Drug Carrier Systems.
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Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.