Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
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Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
TL;DR: This review focuses on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators.
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Biomedical Applications of Supramolecular Systems Based on Host-Guest Interactions.
Xing Ma,Yanli Zhao +1 more
TL;DR: Host−Guest Supramolecular Chemistry A 1.1.1: Aims to explore the role of “ghostly” particles in the determination of chiral stationary phases and their role in the “spatially modified” states.
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Hydrogels in a historical perspective: from simple networks to smart materials.
Sytze J. Buwalda,Kristel W. M. Boere,Pieter J. Dijkstra,Jan Feijen,Tina Vermonden,Wim E. Hennink +5 more
TL;DR: A historical overview of the developments in hydrogel research from simple networks to smart materials is provided to overcome several challenges to overcome for clinical translation.
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TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Christopher B. Rodell,Sean P. Arlauckas,Michael F. Cuccarese,Christopher Garris,Ran Li,Maaz S. Ahmed,Rainer H. Kohler,Mikael J. Pittet,Ralph Weissleder +8 more
TL;DR: The ability of rationally engineered drug–nanoparticle combinations to efficiently modulate tumour-associated macrophages for cancer immunotherapy is demonstrated and R848, an agonist of the toll-like receptors TLR7 and TLR8 identified in a morphometric-based screen, is a potent driver of the M1 phenotype in vitro.
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Supramolecular Architectures of β-Cyclodextrin-Modified Chitosan and Pyrene Derivatives Mediated by Carbon Nanotubes and Their DNA Condensation
TL;DR: The DNA condensation abilities of 1-4 were validated by AFM and dynamic light scattering, which indicates that the DNA-condensing capability of CHIT can be pronouncedly improved by either the pyrene grafts or the MWCNT medium.
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Cyclodextrin complexation: influence on the solubility, stability, and cytotoxicity of camptothecin, an antineoplastic agent.
TL;DR: The results showed that CDs, in general, and RDM-beta-CD, in particular, are effective complexing agents and can be used to improve the solubility and stability of CPT.
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Preclinical to clinical development of the novel camptothecin nanopharmaceutical CRLX101.
TL;DR: The CRLX101 preclinical and clinical data confirm that CDP can address not only solubility, formulation, toxicity, and pharmacokinetic challenges associated with administration of CPT, but more importantly, can impart unique biological properties, that enhance pharmacodynamics and efficacy of camptothecin.
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Cell transfection with polycationic cyclodextrin vectors.
TL;DR: Results indicate that CDs are useful templates for further modification to produce molecular constructs capable of enhanced gene delivery, and imply that intracellular trafficking but not cellular uptake, may be the rate-limiting step in the transfection process.
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Self-Assembling Hydrogels Based on β-Cyclodextrin/Cholesterol Inclusion Complexes
Frank van de Manakker,Martin van der Pot,Tina Vermonden,Cornelus F. van Nostrum,Wim E. Hennink +4 more
TL;DR: Rheological analysis as well as 2D-NMR spectroscopy demonstrated that the obtained gels are due to formation of β-CD/cholesterol inclusion complexes, and hydrogels are fully thermoreversible upon repetitive heating and cooling steps.