scispace - formally typeset
Open AccessJournal ArticleDOI

Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.

Jianxiang Zhang, +1 more
- 01 Aug 2013 - 
- Vol. 65, Iss: 9, pp 1215-1233
Reads0
Chats0
TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.
About
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.

read more

Citations
More filters
Journal ArticleDOI

Cellular Interaction and Tumoral Penetration Properties of Cyclodextrin Nanoparticles on 3D Breast Tumor Model.

TL;DR: It was determined that the nanoparticles prepared from the inclusion complex according to characterization studies have a longer release profile than the conventionally prepared nanoparticles and have a stronger anti-tumoral activity in the 3D multicellular tumor model than the drug solution.
Journal ArticleDOI

Enhanced chemotherapeutic toxicity of cyclodextrin templated size-tunable rhodamine 6G nanoGUMBOS.

TL;DR: The role of cyclodextrin (CD)-templating on the size and therapeutic properties of rhodamine 6G (R6G) nanoGUMBOS, i.e. nanomaterials derived from a Group of Uniform Materials Based on Organic Salts (GUMbOS), is reported to provide further insight into an approach that may be employed for rapid synthesis of size tunable nanodrugs for enhanced chemotherapeutic efficacy.
Journal ArticleDOI

Specific and nonspecific effects of biologically active inorganic salts on inclusion complex formation of cyclodextrins with aromatic carboxylic acids

TL;DR: In this article, the ion-binding between inorganic univalent anions and positively charged groups of the acids under study was analyzed using 3D-RISM approach and it was found that the binding affinity of cyclodextrins to the acids is decreased in the presence of the salts.
Journal ArticleDOI

Complexation of tropane alkaloids by cyclodextrins.

TL;DR: It has been demonstrated that tropane alkaloids form complexes with β- and γ-cyclodextrins of 1:1 stoichiometry and it has been found that β- cyclodextrin forms ten times more stable complexes than γ, which indicates the formation of complexes where both aliphatic and aromatic parts of tropan alkaloid interact withβ-cyclodesxtrin.
References
More filters
Journal ArticleDOI

Effect of pegylation on pharmaceuticals

TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
Journal ArticleDOI

Acidification of the endocytic and exocytic pathways

TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.
Related Papers (5)