Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
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Journal Article
Self assembled cyclodextrin nanoparticles as drug carrier
Pankaj Patil,Satish V. Rojekar +1 more
TL;DR: Different case studies in support of gene delivery, artemisinin nano-carrier system, and nanogel in ocular drug delivery have been discussed to give a better understanding of the various possibilities in CD nano carrier design.
Journal ArticleDOI
Thiolated β-cyclodextrin modified iron oxide nanoparticles for effective targeted cancer therapy
Jyotsna M. Nayak,Kumari Sunita Prajapati,Shashank Kumar,Vinod Kumar Vashistha,Suban K. Sahoo,Rajender Kumar +5 more
TL;DR: Inspired by the mitochondria iron-sulfur protein, direct functionalization of thiolated β-cyclodextrin (β-CD-SH) on iron oxide nanoparticles (IONPs) through Fe-S bond was done as mentioned in this paper .
Journal ArticleDOI
Smart regioselectivity towards mono 6-hydroxyl α-cyclodextrin amphiphilic derivatives
TL;DR: The scope of green and economical access is extended from penta-pentenyl substitution to C4–C6 alkyl group substitution, and the novel procedure minimized the tedious protection, deprotection steps and provided useful intermediates for further cutting edge research.
Book ChapterDOI
Impact of Cyclodextrin in Drug Delivery System
TL;DR: This review analyzes the biochemical and drug delivery aspects of cyclodextrin, which provide extreme flexibility in design of chemical structures and complexes, viability of using multiple drugs with varying release rates and administration mechanisms.
Journal ArticleDOI
Paclitaxel interaction with cucurbit [7]uril and acyclic Cucurbit[4]uril nanocontainers: A computational approach.
TL;DR: This research supports the potential use of the cucurbit[n]urils and their acyclic derivatives as drug delivery systems and clarifies how the flexibility of containers is influenced by their structure and how this affects their interactions with PTX.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
Journal ArticleDOI
Cyclodextrin Drug Carrier Systems.
Journal ArticleDOI
Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.