Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
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Applications of bone regeneration hydrogels in the treatment of bone defects: a review
Yukun Xiong,Yuzhu Xiong +1 more
TL;DR: The methods of bone regeneration hydrogels in the treatment of bone defects will be introduced, promoting differentiation and proliferation of osteoblasts, promoting angiogenesis, regulating immune response and promoting mineralization.
Journal ArticleDOI
Polymeric Gene Carriers Bearing Pendant β-Cyclodextrin: The Relevance of Glycoside Permethylation on the "In Vitro" Cell Response.
Juan Alfonso Redondo,Enrique Martínez-Campos,Laetitia Plet,Laetitia Plet,Mónica Pérez-Perrino,Rodrigo Navarro,Guillermo Corrales,Abhay Pandit,Helmut Reinecke,Alberto Gallardo,José Luis López-Lacomba,Alfonso Fernández-Mayoralas,Carlos Elvira +12 more
TL;DR: The relevance of β-CD permethylation has been addressed by preparing and evaluating two series of copolymers of the cationic N-ethyl pyrrolidine methacrylamide (EPA) and styrenic units bearing pendant hydroxylated and permethylated β- CDs (HCDSt and MeCDSt, respectively).
Journal ArticleDOI
Supramolecular dendritic polymers for diagnostic and theranostic applications
TL;DR: The design and synthesis of SDPs with aimed structures, properties, functions as well as their present diagnostic and theranostic applications are summarized.
Journal ArticleDOI
Controllable drug uptake and nongenomic response through estrogen-anchored cyclodextrin drug complex.
Juan Juan Yin,Juan Juan Yin,Stepan P. Shumyak,Christopher Burgess,Zhi Wei Zhou,Zhi Xu He,Xueji Zhang,Shu Ting Pan,Shu Ting Pan,Tian Xin Yang,Wei Duan,Jia Xuan Qiu,Shu-Feng Zhou +12 more
TL;DR: The results demonstrate a targeted therapeutics delivery of CDE1-Ada-DOX to breast cancer cells in a controlled manner and that the drug vectorCDE1 can potentially be employed as a molecular tool to differentiate nongenomic from genomic mechanism.
Book ChapterDOI
Nanoconstructs Based on Cyclodextrins for Antimicrobial Applications
TL;DR: Nanotherapeutics based on cyclodextrins have been designed to fight the antibiotic resistance and guarantee a successful outcome and photo-antimicrobial chemotherapy strategies based on the use of CD nanocarriers delivering antibiotics/antibacterials, antivirals, antifungals, disinfectants, and antiseptics are reviewed.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
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Cyclodextrin Drug Carrier Systems.
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Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.