Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
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Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
TL;DR: This review focuses on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators.
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Biomedical Applications of Supramolecular Systems Based on Host-Guest Interactions.
Xing Ma,Yanli Zhao +1 more
TL;DR: Host−Guest Supramolecular Chemistry A 1.1.1: Aims to explore the role of “ghostly” particles in the determination of chiral stationary phases and their role in the “spatially modified” states.
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Hydrogels in a historical perspective: from simple networks to smart materials.
Sytze J. Buwalda,Kristel W. M. Boere,Pieter J. Dijkstra,Jan Feijen,Tina Vermonden,Wim E. Hennink +5 more
TL;DR: A historical overview of the developments in hydrogel research from simple networks to smart materials is provided to overcome several challenges to overcome for clinical translation.
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TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Christopher B. Rodell,Sean P. Arlauckas,Michael F. Cuccarese,Christopher Garris,Ran Li,Maaz S. Ahmed,Rainer H. Kohler,Mikael J. Pittet,Ralph Weissleder +8 more
TL;DR: The ability of rationally engineered drug–nanoparticle combinations to efficiently modulate tumour-associated macrophages for cancer immunotherapy is demonstrated and R848, an agonist of the toll-like receptors TLR7 and TLR8 identified in a morphometric-based screen, is a potent driver of the M1 phenotype in vitro.
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Biotechnological applications of cyclodextrins
TL;DR: Recent applications of CDs in pharmaceuticals with a major emphasis on drug delivery systems are described and the utility of these water-soluble cyclic glucans in a variety of foods, flavors cosmetics, packaging and textiles is elaborated.
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PEG-Detachable Polyplex Micelles Based on Disulfide-Linked Block Catiomers as Bioresponsive Nonviral Gene Vectors
Seiji Takae,Kanjiro Miyata,Makoto Oba,Takehiko Ishii,Nobuhiro Nishiyama,Keiji Itaka,Yuichi Yamasaki,Hiroyuki Koyama,Kazunori Kataoka +8 more
TL;DR: Findings suggest that the PEG-SS-P[Asp(DET)] micelle may have promising potential as a nonviral gene vector exerting high transfection with regulated timing and minimal cytotoxicity.
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Photoswitchable gel assembly based on molecular recognition
Hiroyasu Yamaguchi,Yuichiro Kobayashi,Ryosuke Kobayashi,Yoshinori Takashima,Akihito Hashidzume,Akira Harada +5 more
TL;DR: It is demonstrated that macroscopic gel assembly can be highly regulated through photoisomerization of an azobenzene moiety that interacts differently with two host molecules.
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Photoswitchable supramolecular hydrogels formed by cyclodextrins and azobenzene polymers.
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Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA
Jeremy D. Heidel,Zhongping Yu,Joanna Yi-Ching Liu,Shyam M. Rele,Yongchao Liang,Ryan K. Zeidan,Douglas J. Kornbrust,Mark E. Davis +7 more
TL;DR: The results of administering escalating, i.v. doses of targeted nanoparticles containing a siRNA targeting the M2 subunit of ribonucleotide reductase to nonhuman primates are reported.