Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
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Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
TL;DR: This review focuses on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators.
Journal ArticleDOI
Biomedical Applications of Supramolecular Systems Based on Host-Guest Interactions.
Xing Ma,Yanli Zhao +1 more
TL;DR: Host−Guest Supramolecular Chemistry A 1.1.1: Aims to explore the role of “ghostly” particles in the determination of chiral stationary phases and their role in the “spatially modified” states.
Journal ArticleDOI
Hydrogels in a historical perspective: from simple networks to smart materials.
Sytze J. Buwalda,Kristel W. M. Boere,Pieter J. Dijkstra,Jan Feijen,Tina Vermonden,Wim E. Hennink +5 more
TL;DR: A historical overview of the developments in hydrogel research from simple networks to smart materials is provided to overcome several challenges to overcome for clinical translation.
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TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Christopher B. Rodell,Sean P. Arlauckas,Michael F. Cuccarese,Christopher Garris,Ran Li,Maaz S. Ahmed,Rainer H. Kohler,Mikael J. Pittet,Ralph Weissleder +8 more
TL;DR: The ability of rationally engineered drug–nanoparticle combinations to efficiently modulate tumour-associated macrophages for cancer immunotherapy is demonstrated and R848, an agonist of the toll-like receptors TLR7 and TLR8 identified in a morphometric-based screen, is a potent driver of the M1 phenotype in vitro.
References
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Amphiphilic N -glycosyl -thiocarbamoyl cyclodextrins : Synthesis, self-assembly, and fluorimetry of recognition by Lens culinaris lectin
Simone McNicholas,A. Rencurosi,Luigi Lay,Antonino Mazzaglia,Luisa Sturiale,Marta Perez,Raphael Darcy +6 more
TL;DR: Self-assembly of these new amphiphilic glycosylated cyclodextrins in water to form vesicles was investigated by dynamic light scattering and transmission electron microscopy and selective binding of the hexylthio assemblies to a protein receptor was confirmed by fluorescence spectroscopy.
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Synthesis of Novel Supramolecular Assemblies Based on Hyaluronic Acid Derivatives Bearing Bivalent β-Cyclodextrin and Adamantane Moieties
TL;DR: In this paper, a supramolecular assembly based on hyaluronic acid stabilized by divalent β-cyclodextrin/adamantane (β-CD/AD) complexes was synthesized with the aim to compare their viscoelastic behavior in aqueous medium with systems resulting from monovalent complexes.
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A cyclodextrin-based nanoassembly with bimodal photodynamic action.
Noufal Kandoth,Elisa Vittorino,Maria Teresa Sciortino,Tiziana Parisi,Ivana Colao,Antonino Mazzaglia,Salvatore Sortino +6 more
TL;DR: The convergence of the dual therapeutic action and the imaging capacities in one single structure makes this supramolecular architecture an appealing, multifunctional candidate for applications in biomedical research.
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Polyrotaxanes: synthesis, structure, and potential in drug delivery.
Tooru Ooya,Nobuhiko Yui +1 more
TL;DR: The proposed synthetic method for biodegradable polyrotaxanes, the conjugation with drugs, and their association under physiological conditions suggest the potential of poly rotaxanes in pharmaceutical applications.
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Synthesis and characterization of an amphiphilic cyclodextrin, a micelle with two recognition sites.
TL;DR: A cyclodextrin derivative that can form large aggregates not only through the interaction of the hydrophobic tails as in common amphiphilic compounds but also through the inclusion of the alkenyl chain into the cavity of another Mod-CD molecule is an interesting surfactant.