Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
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Co-delivery of 5-fluorouracil and miRNA-34a mimics by host-guest self-assembly nanocarriers for efficacious targeted therapy in colorectal cancer patient-derived tumor xenografts
Jianbin Xu,Guolin Zhang,Xin Luo,Di Wang,Wei Zhou,Yan Zhang,Wei Zhang,Jiaxin Chen,Qing Meng,Engeng Chen,Heng Chen,Zhangfa Song +11 more
TL;DR: In this article, a well-defined targeted quantum dot (QD)-based multifunctional nanocarriers were developed through self-assembly driven by host-guest interactions.
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Cyclodextrin-based star polymers as a versatile platform for nanochemotherapeutics: Enhanced entrapment and uptake of idarubicin
TL;DR: CD star polymers can be considered a versatile platform for a new class of biocompatible nanochemotherapy, as revealed by the pH-titration curves.
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Predicting the binding free energy of the inclusion process of 2-hydroxypropyl-β-cyclodextrin and small molecules by means of the MM/3D-RISM method
Masatake Sugita,Fumio Hirata +1 more
TL;DR: It is suggested that the protocol proposed here is promising for predicting the binding affinity of a small ligand to a relatively rigid receptor such as cyclodextrin.
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Fatty acid profile of Romanian's common bean (Phaseolus vulgaris L.) lipid fractions and their complexation ability by β-cyclodextrin.
Ioan David,Manuela Dora Orboi,Marius D. Simandi,Cosmina A. Chirilă,Corina I. Megyesi,Laura Rădulescu,Lavinia Paula Draghia,Alexandra Teodora Lukinich-Gruia,Cornelia Muntean,Daniel I. Hădărugă,Nicoleta G. Hădărugă +10 more
TL;DR: Findings support the molecular inclusion process of FA moieties into the β-CD cavity by restricting the vibration and bending of some bonds from the host and guest molecules.
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Polymer microspheres with high drug-loading capacity via dual-modal drug-loading for modulating controlled release property in pH/reduction dual-responsive tumor-specific intracellular triggered doxorubicin release
Peng Liu,Ruinian Zhang +1 more
TL;DR: Dual-modal drug-loaded DDS, DOX/P(FPA-co-ACD)C+N, were fabricated with a higher drug-loading capacity (DLC) of >53% via both acid-labile Schiff-base conjugation and host-guest inclusion complexation, demonstrating the controlled release behavior of such DDS could be modulated with dual-modAL drug- loading.
References
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Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI
Complexation Thermodynamics of Cyclodextrins.
Journal ArticleDOI
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
Journal ArticleDOI
Cyclodextrin Drug Carrier Systems.
Journal ArticleDOI
Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.