Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
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Supramolecular topological hydrogels: from material design to applications
TL;DR: Supramolecular topological hydrogels are constructed by introducing different dynamic topological structures into polymeric networks and thus exhibit a wide variety of stimuli-responsive properties and versatile applications as discussed by the authors .
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Molecular recognition of flunarizine dihydrochloride and β-cyclodextrin inclusion complex by NMR and computational approaches.
TL;DR: The splitting of aromatic signals of FLN in the presence ofβ-CD suggests chiral differentiation of the guest FLN by β-CD, and NMR spectroscopic studies of FLn, β- CD and FLN confirmed the formation of 1:1 inclusion complex in solution at room temperature.
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Colloidal-electrochemical fabrication strategies for functional composites of linear polyethylenimine
TL;DR: Electrophoretic deposition and PC-EPD are versatile methods, which allow for the deposition of novel LPEI based composites containing various functional materials, and Hemoglobin was used as a model protein for the fabrication of composite films.
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Cyclodextrin-assisted modulation of the photophysical properties and acidity constant of pyrene-armed calix[4]arene.
TL;DR: P-tert-Butylcalix[4]arene-di-4-(pyren-1-yl)butanoic acid (PCX4) has been synthesized and characterized by 1H NMR, FT-IR and mass spectrometry, and the intrinsic fluorescence from the pyrene moiety of PCX4 is employed to determine the pKa value.
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Solubility enhancement of poorly water soluble domperidone by complexation with the large ring cyclodextrin
Abbas Ismail,Khanittha Kerdpol,Thanyada Rungrotmongkol,Kanitha Tananuwong,Takafumi Ueno,Sanong Ekasit,Nongnuj Muangsin,Kuakarun Krusong +7 more
TL;DR: In this article, the phase solubility profile of mixture LR-CD/DMP was classified as AN-type, resulting in an increase in DMP's water-solubility by 3-fold.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
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Cyclodextrin Drug Carrier Systems.
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Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.