Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
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Supramolecular Helical Nanofibers Formed by Achiral Monomers and Their Reversible Sol-Gel Transition.
TL;DR: Well-defined supramolecular helical nanofibers have been constructed by a rationally designed achiral monomer in aqueous solution based on the 1:2 host-guest combination between cucurbit[8]uril and a 4,4'-bipyridin-1-ium chloride (BPY+ ) salt derivative.
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Advances of cyclodextrin polymers for the delivery of biotech drugs
Yanpeng Liu,Jianshu Li +1 more
TL;DR: This review highlights the structure-function relationship of CDPs to their performance in biotech drug delivery and proposes an outlook on the developing trends and challenge in this field.
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β-Cyclodextrin-Based Nanosponges Functionalized with Drugs and Gold Nanoparticles.
TL;DR: In this paper, the authors developed a new nanomaterial based on β-cyclodextrin-based nanosponges (βCDNS) and two therapeutic agents, drugs and AuNPs.
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Thermodynamic parameters for the complexation of water-insoluble betulin derivatives with (2-hydroxypropyl)-γ-cyclodextrin determined by phase-solubility technique combined with capillary zone electrophoresis.
TL;DR: The complexation of betulinic and betulonic acids (BIA and BOA) with (2‐hydroxypropyl)‐γ‐cyclodextrin (HP‐γ-CD) was studied at different temperatures using the method combining phase‐solubility technique and CZE and it was found that the complexation was characterized by negative changes of enthalpy and entropy, that is, it was controlled byEnthalpy changes.
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Nanotechnology-based combinational drug delivery systems for breast cancer treatment
TL;DR: This work synthesized Magnetic Cyclodextrin-polyurethane based nano-composite (Fe3O4-ECA-PU-CD) which is a drug delivery system using a biocompatible magnetic polymer that directs chemotherapeutic drugs to cancerous regions in the body with an external magnet.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
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Cyclodextrin Drug Carrier Systems.
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Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.