Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
Reads0
Chats0
TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
More filters
Journal ArticleDOI
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
TL;DR: This review focuses on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators.
Journal ArticleDOI
Biomedical Applications of Supramolecular Systems Based on Host-Guest Interactions.
Xing Ma,Yanli Zhao +1 more
TL;DR: Host−Guest Supramolecular Chemistry A 1.1.1: Aims to explore the role of “ghostly” particles in the determination of chiral stationary phases and their role in the “spatially modified” states.
Journal ArticleDOI
Hydrogels in a historical perspective: from simple networks to smart materials.
Sytze J. Buwalda,Kristel W. M. Boere,Pieter J. Dijkstra,Jan Feijen,Tina Vermonden,Wim E. Hennink +5 more
TL;DR: A historical overview of the developments in hydrogel research from simple networks to smart materials is provided to overcome several challenges to overcome for clinical translation.
Journal ArticleDOI
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.
Christopher B. Rodell,Sean P. Arlauckas,Michael F. Cuccarese,Christopher Garris,Ran Li,Maaz S. Ahmed,Rainer H. Kohler,Mikael J. Pittet,Ralph Weissleder +8 more
TL;DR: The ability of rationally engineered drug–nanoparticle combinations to efficiently modulate tumour-associated macrophages for cancer immunotherapy is demonstrated and R848, an agonist of the toll-like receptors TLR7 and TLR8 identified in a morphometric-based screen, is a potent driver of the M1 phenotype in vitro.
References
More filters
Journal ArticleDOI
Synthesis of theophylline-polyrotaxane conjugates and their drug release via supramolecular dissociation.
Tooru Ooya,Nobuhiko Yui +1 more
TL;DR: In vitro degradation of the conjugates revealed that theophylline-immobilized alpha-CDs were completely released by hydrolysis of the terminal peptide linkage in the polyrotaxane, indicating that the association of the Conjugates does not induce the steric hindrance but rather enhances the accessibility of enzymes to theTerminal peptide linkages.
Journal ArticleDOI
Structural effects of carbohydrate-containing polycations on gene delivery. 2. Charge center type.
Theresa M. Reineke,Mark E. Davis +1 more
TL;DR: The effect that polycation charge center type has on toxicity and gene delivery efficiency is investigated and it is found that the quaternary ammonium analogues exhibit lower gene expression values and similar toxicities to their amidine analogues.
Journal ArticleDOI
Nanoparticles of cationic amphiphilic cyclodextrins entangling anionic porphyrins as carrier-sensitizer system in photodynamic cancer therapy.
Salvatore Sortino,Antonino Mazzaglia,Luigi Monsù Scolaro,Francesca Marino Merlo,Vincenza Valveri,Maria Teresa Sciortino +5 more
TL;DR: The triplet state of TPPS is efficiently populated, very long-lived and, as a consequence, able to produce singlet oxygen (the essential species for the photodynamic action) with quantum yield comparable to the free TPPS.
Journal ArticleDOI
Micellization of Hydrophobically Modified Cyclodextrins. 1. Micellar Structure
TL;DR: In this paper, a cholesterol derivative was grafted onto a methylated cyclodextrin through a spacer arm, which produces an amphiphilic compound exhibiting high solubility in water.
Journal ArticleDOI
Polycationic Amphiphilic Cyclodextrins for Gene Delivery: Synthesis and Effect of Structural Modifications on Plasmid DNA Complex Stability, Cytotoxicity, and Gene Expression
Alejandro Díaz-Moscoso,Loïc Le Gourriérec,Marta Gómez-García,Juan M. Benito,Patricia Balbuena,Fernando Ortega-Caballero,Nicolas Guilloteau,Christophe Di Giorgio,Pierre Vierling,Jacques Defaye,Carmen Ortiz Mellet,José M. García Fernández +11 more
TL;DR: A molecular-diversity-oriented approach for the preparation of well-defined polycationic amphiphilic cyclodextrins (paCDs) as gene-delivery systems is reported, finding that paCDs self-assemble in the presence of plasmid DNA to provide homogeneous, stable nanoparticles (CDplexes) of 70-150 nm that fully protect pDNA from the environment.