Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
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Book ChapterDOI
Cyclodextrins-based hydrogel
TL;DR: This chapter focuses on key advances of cyclodextrins-based hydrogel development with special emphasis oncyclodextrin-cellulose hydrogels, and relevant aspects regarding structural variations, methods of synthesis, processing and functionalization, and corresponding supramolecular properties are presented.
Journal ArticleDOI
A Hybrid Supramolecular Polymeric Nanomedicine for Cascade‐Amplified Synergetic Cancer Therapy
TL;DR: In this article , a hybrid supramolecular polymeric nanomedicine (SNP) was developed based on β-cyclodextrin/camptothecin (CPT) host−guest molecular recognition and iron-carboxylate coordination.
Journal ArticleDOI
Theoretical Insight and Molecular Recognition of Oxatub[4]arene-based Organic Macrocycle as a Supramolecular Host for Antipsychotic Drug Risperidone
TL;DR: In this article , the formation of two complex conformers of RSP-docked hydroxylated Oxatub[4]arene (HTA4) conformers was analyzed using LOLIPOP and IRI-π analysis.
Journal ArticleDOI
Prediction of the most preferable rotamer of meta -aminophenol in β -cyclodextrin cavity in aqueous medium by using spectroscopic and DFT computational studies
TL;DR: In this article, a host-guest inclusion complex was formed by β-cyclodextrin (β-CD) and Meta-aminophenol (m-AP) in aqueous medium.
Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin
TL;DR: In this article, two different conjugates (G-mPEG-NP and G-HPCD-NP) were synthetized and characterized to evaluate nanoparticles from Gantrez-based conjugate as carriers for the oral delivery of CPT.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
Journal ArticleDOI
Cyclodextrin Drug Carrier Systems.
Journal ArticleDOI
Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.