Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
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pH‐Responsive Indicator Displacement Assay of Acetylcholine Based on Acridine–p‐Sulfonatocalix[4]arene Supramolecular System: Fluorescence Off/On Switching and Reversible pKa Shift
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Inhibition of hypoxia-induced proliferation of pulmonary arterial smooth muscle cells by a mTOR siRNA-loaded cyclodextrin nanovector
Xueping Liu,Guansong Wang,Zaichun You,Pin Qian,Huaping Chen,Yin Dou,Zhenghua Wei,Yan Chen,Chengde Mao,Jianxiang Zhang +9 more
TL;DR: In this paper, the mammalian target of rapamycin (mTOR) siRNA was loaded into hybrid nanoparticles based on low molecular weight polyethylenimine (PEI) and a pH-responsive cyclodextrin material (Ac-aCD) or poly(lactic-co-glycolic acid) (PLGA).
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Cyclodextrin-based delivery systems for dietary pharmaceuticals
TL;DR: The current applications of natural and chemically modified cyclodextrins for the delivery of dietary phytochemicals are reviewed and the main emphasis is given on inclusion complexes for enhancing the solubility, bioavailability and efficacy of dietaryPhytochemicalicals.
Journal ArticleDOI
Actin Cytoskeleton-Disrupting and Magnetic Field-Responsive Multivalent Supramolecular Assemblies for Efficient Cancer Therapy.
TL;DR: Interestingly, with the acid of a low-frequency alternating magnetic field (AMF) (200 Hz), the actin cytoskeleton-targeting nanofibers could induce severe actin disruption, leading to remarkable cell cycle arrest and drastic cell death of tumor cells both in vitro and in vivo, but showed no obvious toxicity to normal cells.
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Hydrogel Transformed from Nanoparticles for Prevention of Tissue Injury and Treatment of Inflammatory Diseases
Zimeng Li,Gang Li,Jiajia Xu,Chenwen Li,Songling Han,Chunfan Zhang,Peng Wu,Yong-Qun Lin,Chenping Wang,Jianxiang Zhang,Xiaodong Li +10 more
TL;DR: The engineered transformable nanoparticles hold great promise in tissue injury protection and site‐specific/local delivery of molecular and cellular therapeutic agents in response to the physiologically and pathologically acidic microenvironment.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
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Cyclodextrin Drug Carrier Systems.
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Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.