Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
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Complex systems that incorporate cyclodextrins to get materials for some specific applications
TL;DR: This mini-review will focus on chemical systems that use cyclodextrins, whatever linked covalently or mediated by the non covalent interactions, to build complex systems developed mainly during the last five years.
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Supramolecular Cyclodextrin Supplements to Improve the Tissue Adhesion Strength of Gelatin Bioglues
TL;DR: It is suggested that the supramolecular networking of CDs, both inside the glue and at the glue-skin interface, could reinforce tissue adhesiveness of bioglues, which allows them to be of great relevance to a primary treatment modality for larger skin incisions.
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Therapeutic gene regulation using pyrrole-imidazole polyamides
TL;DR: The progress in the development of PIP-based designer ligands and their prospects as advanced DNA-based small-molecule drugs for therapeutic gene modulation are detailed.
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Monosubstituted Cyclodextrins as Precursors for Further Use
TL;DR: This review focuses only on the synthesis of several interesting monosubstituted cyclodextrin derivatives suitable for further modifications, which allow the synthesisation of an unlimited number of desired cyclodeXTrin derivatives.
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Cyclodextrin/Paclitaxel Dimer Assembling Vesicles: Reversible Morphology Transition and Cargo Delivery
TL;DR: Stable supramolecular binary vesicles were developed on the basis of the host-guest interaction between β-cyclodextrins (β-CDs) and paclitaxel (PTX) dimer and could evolve to nanoparticles (NPs) by adding competitive binding guest amantadine hydrochloride or by digesting α-amylase.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
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Cyclodextrin Drug Carrier Systems.
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Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.