Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
More filters
Journal ArticleDOI
Thermoresponsive Hydrogel Induced by Dual Supramolecular Assemblies and Its Controlled Release Property for Enhanced Anticancer Drug Delivery.
Xia Song,Zhongxing Zhang,Jingling Zhu,Yuting Wen,Feng Zhao,Lijie Lei,Nhan Phan-Thien,Boo Cheong Khoo,Jun Li +8 more
TL;DR: The dual supramolecular hydrogel developed in this work with remarkable thermoresponsive properties might have potential for sustained anticancer drug delivery with enhanced therapeutic effect in multidrug resistant cancer cells.
Journal ArticleDOI
Supramolecular self-assembled nanoparticles for chemo-photodynamic dual therapy against cisplatin resistant cancer cells
TL;DR: Supramolecular self-assembled nanoparticles that can overcome cisplatin resistance were constructed by utilizing a platinum(IV) prodrug bridged β-cyclodextrin dimer and adamantyl group modified porphyrin as the host and guest molecules, respectively.
Journal ArticleDOI
From Supramolecular Vesicles to Micelles: Controllable Construction of Tumor-Targeting Nanocarriers Based on Host–Guest Interaction between a Pillar[5]arene-Based Prodrug and a RGD-Sulfonate Guest
Xiao-Yu Hu,Xiao-Yu Hu,Xiao-Yu Hu,Lei Gao,Stefanie Mosel,Martin Ehlers,Elio Zellermann,Hao Jiang,Shirley K. Knauer,Leyong Wang,Carsten Schmuck +10 more
TL;DR: In vitro and in vivo studies reveal that both these prodrug nanocarriers could selectively deliver doxorubicin to RGD receptor-overexpressing cancer cells, leading to longer blood retention time, enhanced antitumor efficacy, and reduced systematic toxicity in murine tumor model, suggesting their potential application for targeted drug delivery.
Journal ArticleDOI
Hydrogels for Atopic Dermatitis and Wound Management: A Superior Drug Delivery Vehicle.
Ian P. Harrison,Fabrizio Spada +1 more
TL;DR: A brief overview of the history and characteristics of hydrogels, assess their uses in wound management and drug delivery, and compare them with other types of common drug delivery vehicle are provided.
Journal ArticleDOI
Inclusion complex between beta-cyclodextrin and phenylphosphonicdiamide as novel bio-based flame retardant to epoxy: Inclusion behavior, characterization and flammability
TL;DR: In this article, the authors studied the impact of inclusion complex (IC) between β-cyclodextrin (β-CD) and N, N′-diamyl-p-phenylphosphonicdiamide (P-MA) on the thermal stability and flame retardancy of epoxy resin (EP).
References
More filters
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI
Complexation Thermodynamics of Cyclodextrins.
Journal ArticleDOI
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
Journal ArticleDOI
Cyclodextrin Drug Carrier Systems.
Journal ArticleDOI
Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.