Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
Citations
More filters
Journal ArticleDOI
EDTA capped iron oxide nanoparticles magnetic micelles: drug delivery vehicle for treatment of chronic myeloid leukemia and T1–T2 dual contrast agent for magnetic resonance imaging
Ekta Shah,Pratik Upadhyay,Mala Singh,Mohmmad Shoab Mansuri,Rasheedunnisa Begum,Navin Sheth,Hemant P. Soni +6 more
TL;DR: It is proposed that the longitudinal relaxation of water protons can be induced by mimicking Gd-DTPA chelate chemistry while transverse relaxation can be achieved by controlling the particle size.
Journal ArticleDOI
Papain-cyclodextrin complexes as an intestinal permeation enhancer: Permeability and in vitro safety evaluation
Fulvio G. Corazza,Julia V. Ernesto,Felipe A. N. Nambu,Luma Ramirez de Carvalho,Vânia Rodrigues Leite-Silva,Gustavo H.C. Varca,Leandro Augusto Calixto,Daniel Perez Vieira,Newton Andréo-Filho,Patricia Santos Lopes +9 more
TL;DR: The native papain-cyclodextrin complexes are shown to be an oral permeation enhancer to furosemide, using a Caco-2 monolayer system to evaluate drug permeability and apparent permeability coefficient.
Journal ArticleDOI
Synthesis and Drug Delivery Application of Thermo- and pH-Sensitive Hydrogels: Poly(β-CD-co-N-Isopropylacrylamide-co-IAM)
TL;DR: It was reported that poly(NIPAM-IAM) can respond to the change of temperature as well as pH value, and the results show that the lower critical solution temperature of the copolymer (or hydrogel) increases as the molar fraction of IAM increases.
Journal ArticleDOI
New aspects of controlled release systems for local anaesthetics: A review
Alexandru Florin Rogobete,Monica Dragomirescu,Ovidiu Horea Bedreag,Dorel Sandesc,Carmen Alina Cradigati,Mirela Sarandan,Marius Papurica,Sonia Elena Popovici,Corina Vernic,Gabriela Preda +9 more
TL;DR: An update in terms of controlled release systems of local anaesthetics and future outcomes regarding this topic is presented and some of the side effects of conventional therapies have been removed.
Journal ArticleDOI
On-off-on fluorescence detection for biomolecules by a fluorescent cage through host-guest complexation in water
TL;DR: In this paper , a host-guest approach was proposed by using a fluorescent tetraphenylethene-based octacationic cage as host and 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS) as guest and fluorescent indicator to form non-fluorescent 1:1:1 host-(endo-exo)guest complex in water.
References
More filters
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI
Complexation Thermodynamics of Cyclodextrins.
Journal ArticleDOI
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
Journal ArticleDOI
Cyclodextrin Drug Carrier Systems.
Journal ArticleDOI
Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.