Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.
Jianxiang Zhang,Peter X. Ma +1 more
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TLDR
This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery and the future directions of this field are discussed.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-08-01 and is currently open access. It has received 673 citations till now.read more
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Grinding as Solvent-Free Green Chemistry Approach for Cyclodextrin Inclusion Complex Preparation in the Solid State.
Mario Jug,Paola Mura +1 more
TL;DR: A systematic overview of the currently available data in this field of mechanochemical activation by grinding for cyclodextrin inclusion complex preparation in the solid state is given, highlighting both the advantages as well as the shortcomings of such an approach.
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Synthesis of temperature/pH dual-sensitive supramolecular micelles from β-cyclodextrin-poly(N-isopropylacrylamide) star polymer for drug delivery.
TL;DR: Temperature and pH dual-sensitive supramolecular micelles constructed from star polymer β-cyclodextrin-poly(N-isopropylacrylamide) and benzimidazole terminated poly(ε-caprolactone) and BM-PCL exhibited higher anti-cancer activity than free drugs.
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Preparation of stimuli-responsive nano-sized capsules based on cyclodextrin polymers with redox or light switching properties
TL;DR: In this paper, the preparation and encapsulation properties of stimuli-responsive nanocapsules, self-assembled by the noncovalent interactions of cyclodextrin-appended polymers (host) and complementary ferrocene or azobenzene carriers (guest), were reported.
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A novel bioreducible and pH-responsive magnetic nanohydrogel based on β-cyclodextrin for chemo/hyperthermia therapy of cancer.
Khadijeh Soleimani,Elham Arkan,Hossein Derakhshankhah,Babak Haghshenas,Rana Jahanban-Esfahlan,Mehdi Jaymand +5 more
TL;DR: The formulated β-CD-g-(PEtOx)7/Fe3O4-Dox can be considered as an efficient and "smart" DDS for cancer therapy and diagnosis due to its high drug loading value, slow and stimuli-triggered drug release behavior, and acceptable magnetic properties.
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Molecular nanoparticle-based gene delivery systems
TL;DR: The body of work here reviewed illustrates the potential of the MNP concept to produce single isomer constructs that can be programmed to mediate the safe delivery of nucleic acids to the target cells.
References
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Complexation Thermodynamics of Cyclodextrins.
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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
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Cyclodextrin Drug Carrier Systems.
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Acidification of the endocytic and exocytic pathways
TL;DR: The Exocytic Pathway and the CharacTERISTICS of PROTON ATPases are reviewed.