MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.
Xin Yin,Xin Yin,Laura Riva,Yuan Pu,Laura Martin-Sancho,Jun Kanamune,Yuki Yamamoto,Kouji Sakai,Shimpei Gotoh,Lisa Miorin,Paul D. De Jesus,Chih Cheng Yang,Kristina M. Herbert,Sunnie M. Yoh,Judd F. Hultquist,Adolfo García-Sastre,Sumit K. Chanda +16 more
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TLDR
It is found that SARS-CoV-2 replication induces a delayed interferon (IFN) response in lung epithelial cells and that IRF-3, -5, and NF-kB/p65 are the key transcription factors regulating the IFN response during Sars-Cov-2 infection.About:
This article is published in Cell Reports.The article was published on 2021-01-12 and is currently open access. It has received 251 citations till now. The article focuses on the topics: Innate immune system & IRF3.read more
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The signal pathways and treatment of cytokine storm in COVID-19.
TL;DR: In this paper, the authors discuss the latest developments in the immunopathological characteristics of COVID-19 and focus on CS including the current research status of the different cytokines involved, and discuss the induction, function, downstream signaling and existing and potential interventions for targeting these cytokines or related signal pathways.
Journal ArticleDOI
SARS-CoV-2 pathogenesis
Mart M. Lamers,Bart L. Haagmans +1 more
TL;DR: In this paper , the authors explore recent clinical and experimental advances regarding SARS-CoV-2 pathophysiology and discuss potential mechanisms behind acute respiratory distress syndrome (ARDS), specifically focusing on new insights obtained using novel technologies such as single-cell omics, organoid infection models and CRISPR screens.
Journal ArticleDOI
Innate immunity: the first line of defense against SARS-CoV-2
TL;DR: Kanneganti et al. as discussed by the authors reviewed the key role played by innate immunity in the control and immunopathology of COVID-19 and discussed innate immune processes involved in SARS-CoV-2 recognition and the resultant inflammation.
Journal ArticleDOI
Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children.
Jennifer Loske,Jobst Röhmel,Soeren Lukassen,Sebastian Stricker,Vladimir Gonçalves Magalhães,Johannes Liebig,Robert Lorenz Chua,Loreen Thürmann,Marey Messingschlager,Anke Seegebarth,Bernd Timmermann,Sven Klages,Markus Ralser,Birgit Sawitzki,Leif E. Sander,Victor M. Corman,Victor M. Corman,Christian Conrad,Sven Laudi,Marco Binder,Saskia Trump,Roland Eils,Roland Eils,Marcus A. Mall,Irina Lehmann,Irina Lehmann +25 more
TL;DR: In this paper, the authors characterized the single-cell transcriptional landscape in the upper airway of SARS-CoV-2-negative and age-matched children and corresponding samples from adults, covering an age range of 4 weeks to 77 years.
Journal ArticleDOI
SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells.
Antoine Rebendenne,Ana Luiza Chaves Valadão,Marine Tauziet,Ghizlane Maarifi,Boris Bonaventure,Joe McKellar,Rémi Planès,Sébastien Nisole,Mary Arnaud-Arnould,Olivier Moncorgé,Caroline Goujon +10 more
TL;DR: In this paper, the authors characterized in depth host cell responses against SARS-CoV-2 in primary human airway epithelia (HAE) and immortalized cell lines.
References
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Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
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A new coronavirus associated with human respiratory disease in China.
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TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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NF-κB signaling in inflammation
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
David E. Gordon,Gwendolyn M. Jang,Mehdi Bouhaddou,Jiewei Xu,Kirsten Obernier,Kris M. White,Matthew J. O’Meara,Veronica V. Rezelj,Jeffrey Z. Guo,Danielle L. Swaney,Tia A. Tummino,Ruth Hüttenhain,Robyn M. Kaake,Alicia L. Richards,Beril Tutuncuoglu,Helene Foussard,Jyoti Batra,Kelsey M. Haas,Maya Modak,Minkyu Kim,Paige Haas,Benjamin J. Polacco,Hannes Braberg,Jacqueline M. Fabius,Manon Eckhardt,Margaret Soucheray,Melanie J. Bennett,Merve Cakir,Michael McGregor,Qiongyu Li,Bjoern Meyer,Ferdinand Roesch,Thomas Vallet,Alice Mac Kain,Lisa Miorin,Elena Moreno,Zun Zar Chi Naing,Yuan Zhou,Shiming Peng,Ying Shi,Ziyang Zhang,Wenqi Shen,Ilsa T Kirby,James E. Melnyk,John S. Chorba,Kevin Lou,Shizhong Dai,Inigo Barrio-Hernandez,Danish Memon,Claudia Hernandez-Armenta,Jiankun Lyu,Christopher J.P. Mathy,Tina Perica,Kala Bharath Pilla,Sai J. Ganesan,Daniel J. Saltzberg,Rakesh Ramachandran,Xi Liu,Sara Brin Rosenthal,Lorenzo Calviello,Srivats Venkataramanan,Jose Liboy-Lugo,Yizhu Lin,Xi Ping Huang,Yongfeng Liu,Stephanie A. Wankowicz,Markus Bohn,Maliheh Safari,Fatima S. Ugur,Cassandra Koh,Nastaran Sadat Savar,Quang Dinh Tran,Djoshkun Shengjuler,Sabrina J. Fletcher,Michael C. O’Neal,Yiming Cai,Jason C.J. Chang,David J. Broadhurst,Saker Klippsten,Phillip P. Sharp,Nicole A. Wenzell,Duygu Kuzuoğlu-Öztürk,Hao-Yuan Wang,Raphael Trenker,Janet M. Young,Devin A. Cavero,Devin A. Cavero,Joseph Hiatt,Joseph Hiatt,Theodore L. Roth,Ujjwal Rathore,Ujjwal Rathore,Advait Subramanian,Julia Noack,Mathieu Hubert,Robert M. Stroud,Alan D. Frankel,Oren S. Rosenberg,Kliment A. Verba,David A. Agard,Melanie Ott,Michael Emerman,Natalia Jura,Mark von Zastrow,Eric Verdin,Eric Verdin,Alan Ashworth,Olivier Schwartz,Christophe d'Enfert,Shaeri Mukherjee,Matthew P. Jacobson,Harmit S. Malik,Danica Galonić Fujimori,Trey Ideker,Charles S. Craik,Stephen N. Floor,James S. Fraser,John D. Gross,Andrej Sali,Bryan L. Roth,Davide Ruggero,Jack Taunton,Tanja Kortemme,Pedro Beltrao,Marco Vignuzzi,Adolfo García-Sastre,Kevan M. Shokat,Brian K. Shoichet,Nevan J. Krogan +128 more
TL;DR: A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.
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