Journal ArticleDOI
Origin and function of the major royal jelly proteins of the honeybee (Apis mellifera) as members of the yellow gene family.
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TLDR
Research on major royal jelly proteins in honeybees and in hymenopteran insects in general is reviewed and metadata analyses on genome organisation of mrjp genes are provided, corroborating previous reports that MRJPs have important functions for insect development and not just a nutritional value for developing honeybee larvae.Abstract:
In the honeybee, Apis mellifera, the queen larvae are fed with a diet exclusively composed of royal jelly (RJ), a secretion of the hypopharyngeal gland of young worker bees that nurse the brood. Up to 15% of RJ is composed of proteins, the nine most abundant of which have been termed major royal jelly proteins (MRJPs). Although it is widely accepted that RJ somehow determines the fate of a female larva and in spite of considerable research efforts, there are surprisingly few studies that address the biochemical characterisation and functions of these MRJPs. Here we review the research on MRJPs not only in honeybees but in hymenopteran insects in general and provide metadata analyses on genome organisation of mrjp genes, corroborating previous reports that MRJPs have important functions for insect development and not just a nutritional value for developing honeybee larvae.read more
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The genomes of two key bumblebee species with primitive eusocial organization
Ben M. Sadd,Ben M. Sadd,Seth M. Barribeau,Seth M. Barribeau,Guy Bloch,Dirk C. de Graaf,Peter K. Dearden,Christine G. Elsik,Christine G. Elsik,Jürgen Gadau,Cornelis J. P. Grimmelikhuijzen,Martin Hasselmann,Jeffrey D. Lozier,Hugh M. Robertson,Guy Smagghe,Eckart Stolle,Matthias Van Vaerenbergh,Robert M. Waterhouse,Erich Bornberg-Bauer,Steffen Klasberg,Anna K. Bennett,Francisco Câmara,Roderic Guigó,Katharina J. Hoff,Marco Mariotti,Monica Munoz-Torres,Monica Munoz-Torres,Terence Murphy,Didac Santesmasses,Gro V. Amdam,Matthew Beckers,Martin Beye,Matthias Biewer,Matthias Biewer,Márcia Maria Gentile Bitondi,Mark Blaxter,Andrew F. G. Bourke,Mark J. F. Brown,Séverine D. Buechel,Rossanah Cameron,Kaat Cappelle,James C. Carolan,Olivier Christiaens,Kate L. Ciborowski,David F. Clarke,Thomas J. Colgan,David Collins,Andrew G. Cridge,Tamas Dalmay,Stephanie Dreier,Louis du Plessis,Louis du Plessis,Elizabeth J. Duncan,Silvio Erler,Jay D. Evans,Tiago Falcon,Kevin B. Flores,Flávia Cristina de Paula Freitas,Taro Fuchikawa,Taro Fuchikawa,Tanja Gempe,Klaus Hartfelder,Frank Hauser,Sophie Helbing,Fernanda C. Humann,Frano Irvine,Lars S. Jermiin,Claire E. Johnson,Reed M. Johnson,Andrew K. Jones,Tatsuhiko Kadowaki,Jonathan H. Kidner,Vasco Koch,Arian Köhler,F. Bernhard Kraus,H. Michael G. Lattorff,Megan Leask,Gabrielle A. Lockett,Eamonn B. Mallon,David S. Marco Antonio,Monika Marxer,Ivan Meeus,Robin F. A. Moritz,Ajay Nair,Kathrin Näpflin,Inga Nissen,Jinzhi Niu,Francis M. F. Nunes,John G. Oakeshott,Amy J. Osborne,Marianne Otte,Daniel Guariz Pinheiro,Nina Rossié,Olav Rueppell,Carolina G. Santos,Regula Schmid-Hempel,Björn D. Schmitt,Christina Schulte,Zilá Luz Paulino Simões,Michelle P.M. Soares,Luc Swevers,Eva C. Winnebeck,Florian Wolschin,Florian Wolschin,Na Yu,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Peshtewani K. Aqrawi,Kerstin P. Blankenburg,Marcus Coyle,Liezl Francisco,Alvaro G. Hernandez,Michael Holder,Matthew E. Hudson,LaRonda Jackson,Joy Jayaseelan,Vandita Joshi,Christie Kovar,Sandra L. Lee,Robert Mata,Tittu Mathew,Irene Newsham,Robin Ngo,Geoffrey Okwuonu,Christopher Pham,Ling-Ling Pu,Nehad Saada,Jireh Santibanez,DeNard Simmons,Rebecca Thornton,Aarti Venkat,Kimberly K. O. Walden,Yuanqing Wu,Griet Debyser,Bart Devreese,Claire Asher,Julie Blommaert,Ariel D. Chipman,Lars Chittka,Bertrand Fouks,Bertrand Fouks,Jisheng Liu,Jisheng Liu,Meaghan P. O’Neill,Seirian Sumner,Daniela Puiu,Jiaxin Qu,Steven L. Salzberg,Steven E. Scherer,Donna M. Muzny,Stephen Richards,Gene E. Robinson,Richard A. Gibbs,Paul Schmid-Hempel,Kim C. Worley +154 more
TL;DR: Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation.
Journal ArticleDOI
Genomic signatures of evolutionary transitions from solitary to group living
Karen M. Kapheim,Karen M. Kapheim,Hailin Pan,Cai Li,Steven L. Salzberg,Steven L. Salzberg,Daniela Puiu,Tanja Magoc,Hugh M. Robertson,Matthew E. Hudson,Aarti Venkat,Aarti Venkat,Brielle J. Fischman,Brielle J. Fischman,Alvaro G. Hernandez,Mark Yandell,Daniel D. Ence,Carson Holt,George D. Yocum,William P. Kemp,Jordi Bosch,Robert M. Waterhouse,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Eckart Stolle,Eckart Stolle,F. Bernhard Kraus,Sophie Helbing,Robin F. A. Moritz,Karl M. Glastad,Brendan G. Hunt,Michael A. D. Goodisman,Frank Hauser,Cornelis J. P. Grimmelikhuijzen,Daniel Guariz Pinheiro,Daniel Guariz Pinheiro,Francis M. F. Nunes,Michelle P.M. Soares,E. D. Tanaka,Zilá Luz Paulino Simões,Klaus Hartfelder,Jay D. Evans,Seth M. Barribeau,Reed M. Johnson,Jonathan Massey,Jonathan Massey,Bruce R. Southey,Martin Hasselmann,Daniel Hamacher,Matthias Biewer,Clement F. Kent,Clement F. Kent,Amro Zayed,Charles Blatti,Saurabh Sinha,J. Spencer Johnston,Shawn J. Hanrahan,Sarah D. Kocher,Jun Wang,Gene E. Robinson,Guojie Zhang +60 more
TL;DR: There is no single road map to eusociality; independent evolutionary transitions in sociality have independent genetic underpinnings and these transitions do have similar general features, including an increase in constrained protein evolution accompanied by increases in the potential for gene regulation and decreases in diversity and abundance of transposable elements.
Journal ArticleDOI
Royal Jelly: An ancient remedy with remarkable antibacterial properties
TL;DR: The results of antimicrobial studies of Royal Jelly are summarized from the first scientific applications to the isolation of the single components in order to better understand its application in the past years and propose an employment in future studies as a natural antimicrobial agent.
Journal ArticleDOI
Nutritional Physiology and Ecology of Honey Bees
TL;DR: Research clearly shows that bees regulate their intake, like other animals, around specific proportions of macronutrients, done as individuals and at the colony level by foragers.
Journal ArticleDOI
New Insights into the Biological and Pharmaceutical Properties of Royal Jelly
TL;DR: The recent research advances on the main bioactive compounds of RJ are highlighted, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits.
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Journal ArticleDOI
Insights into social insects from the genome of the honeybee Apis mellifera
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TL;DR: The genome sequence of the honeybee Apis mellifera is reported, suggesting a novel African origin for the species A. melliferA and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.
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TL;DR: The new web interface provides, in particular, visual guidance for newcomers to ExPASy, becoming an extensible and integrative portal accessing many scientific resources, databases and software tools in different areas of life sciences.
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