Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
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Journal ArticleDOI
Cyclodextrins and their uses: a review
TL;DR: Cyclodextrins are a family of cyclic oligosaccharides composed of α-(1,4) linked glucopyranose subunits.
Journal ArticleDOI
Improving drug solubility for oral delivery using solid dispersions.
TL;DR: The historical background and definitions of the various systems including eutectic mixtures, solid dispersions and solid solutions, as well as the production, the different carriers and the methods used for the characterization of solid dispersion are outlined.
Journal ArticleDOI
Cyclodextrin Drug Carrier Systems.
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Cyclodextrins as pharmaceutical solubilizers.
TL;DR: This review is intended to give a general background to the use of cyclodextrin as solubilizers as well as highlight kinetic and thermodynamic tools and parameters useful in the study of drug Solubilization bycyclodextrins.
Journal ArticleDOI
Cyclodextrin-based pharmaceutics: past, present and future
Mark E. Davis,Marcus E. Brewster +1 more
TL;DR: Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.
References
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Journal ArticleDOI
Interaction of Prostaglandin E1 with α-Cyclodextrin in Aqueous Systems: Stability of the Inclusion Complex
TL;DR: Nuclear magnetic resonance measurements have been made to study the interaction of PGE1 with alpha-CD and prove that only weak interaction forces are operative and that complete dissociation occurs upon dilution.
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Complexation of 6-ACYL-O-β-Cyclodextrin derivatives with steroids - effects of chain length and substitution degree
TL;DR: In this paper, 6-acyl-o-β-cyclodextrin (β-CD) derivatives with different chain length and substitution degree were synthesized by esterifying the primary hydroxyl groups at 6-position of β-CD with various acyl chlorides.
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Aluminium β‐Cyclodextrin Sulphate as a Stabilizer and Sustained‐release Carrier for Basic Fibroblast Growth Factor
Kazuhiro Fukunaga,Shigeki Hijikata,Kimihiro Ishimura,Ryouichi Sonoda,Tetsumi Irie,Kaneto Uekama +5 more
TL;DR: In this paper, the water-insoluble aluminium salt of beta-cyclodextrin sulphate (Al.beta-CyD-Sul) was used as stabilizer and sustained-release carrier for recombinant human basic fibroblast growth factor (bFGF).
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Hydroxypropyl-beta-cyclodextrin increases the aqueous solubility and stability of pilocarpine prodrugs.
TL;DR: The solubility of the prodrugs was shown to increase markedly in phase-solubility studies and the degradation rate of prodrug in stability studies was show to be slower in the l:2-complex than in thel:l-complex and the relative amounts of complex species were found to be dependent on CD concentration.