Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
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Journal ArticleDOI
Cyclodextrins and their uses: a review
TL;DR: Cyclodextrins are a family of cyclic oligosaccharides composed of α-(1,4) linked glucopyranose subunits.
Journal ArticleDOI
Improving drug solubility for oral delivery using solid dispersions.
TL;DR: The historical background and definitions of the various systems including eutectic mixtures, solid dispersions and solid solutions, as well as the production, the different carriers and the methods used for the characterization of solid dispersion are outlined.
Journal ArticleDOI
Cyclodextrin Drug Carrier Systems.
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Cyclodextrins as pharmaceutical solubilizers.
TL;DR: This review is intended to give a general background to the use of cyclodextrin as solubilizers as well as highlight kinetic and thermodynamic tools and parameters useful in the study of drug Solubilization bycyclodextrins.
Journal ArticleDOI
Cyclodextrin-based pharmaceutics: past, present and future
Mark E. Davis,Marcus E. Brewster +1 more
TL;DR: Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.
References
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Journal ArticleDOI
Cyclodextrin complexation of NSAIDSs: physicochemical characteristics
TL;DR: In this article, the interactions of a number of NSAIDs, i.e. acetylsalicylic acid, ibuprofen, methyl acyclic acid, methyl salicylate, naproxen and tenoxicam, with five cyclodextrin derivatives, was investigated.
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The effect of hydroxypropyl methylcellulose on the release of dexamethasone from aqueous 2-hydroxypropyl-β-cyclodextrin formulations
TL;DR: In this paper, the authors investigated the effect of HPβCD on the aqueous solubility of dexamethasone and showed that a water-soluble 2-hydroxypropyl-β-cyclodextrin (1:1) inclusion complex was formed by the addition of 0.1% hydroxypropyl methylcellulose.
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Interaction of NSA with cyclodextrins and hydroxypropyl cyclodextrin derivatives
TL;DR: In this paper, the effects of hydroxyalkylated cyclodextrins (CD) on the solubility and stability of the nonsteroidal antirheumatics (NSA) diclofenac, piroxicam and indomethacin were investigated.
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The effect of polyvinylpyrrolidone on cyclodextrin complexation of hydrocortisone and its diffusion through hairless mouse skin
TL;DR: Polyvinylpyrrolidone (PVP) increased the complexation of hydrocortisone which increased solubility of the drug in the aqueous cyclodextrin solutions and could be increased even further by addition of oleic acid to the a Queen Elizabeth II-class PVP vehicle systems.