Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
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Journal ArticleDOI
Cyclodextrins and their uses: a review
TL;DR: Cyclodextrins are a family of cyclic oligosaccharides composed of α-(1,4) linked glucopyranose subunits.
Journal ArticleDOI
Improving drug solubility for oral delivery using solid dispersions.
TL;DR: The historical background and definitions of the various systems including eutectic mixtures, solid dispersions and solid solutions, as well as the production, the different carriers and the methods used for the characterization of solid dispersion are outlined.
Journal ArticleDOI
Cyclodextrin Drug Carrier Systems.
Journal ArticleDOI
Cyclodextrins as pharmaceutical solubilizers.
TL;DR: This review is intended to give a general background to the use of cyclodextrin as solubilizers as well as highlight kinetic and thermodynamic tools and parameters useful in the study of drug Solubilization bycyclodextrins.
Journal ArticleDOI
Cyclodextrin-based pharmaceutics: past, present and future
Mark E. Davis,Marcus E. Brewster +1 more
TL;DR: Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.
References
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Journal ArticleDOI
Thermodynamics of molecular recognition by cyclodextrins. 1. Calorimetric titration of inclusion complexation of naphthalenesulfonates with .alpha.-, .beta.-, and .gamma.-cyclodextrins: enthalpy-entropy compensation
TL;DR: In this article, a 1:1 stoichiometry was applied to all of the host-guest combinations employed, except for the inclusion of 2-naphthalenesulfonate 2 with γ-CD.
Journal ArticleDOI
Cyclodextrins and their industrial uses: Dominique Duchêne (Editor), Editions de Santé, 19 rue Louis-le-Grand, 75002 Paris, France, 1987, 448 pages, ISBN 2-86411-019-9.
Journal ArticleDOI
Hydroxypropyl-β-cyclodextrin: preparation and characterization; effects on solubility of drugs
TL;DR: In this paper, conditions for condensation of β-cyclodextrin with propylene oxide were found which give preparations of hydroxypropyl-β-cyclodextrin with a narrow and symmetrical distribution of the degree of substitution.
Book ChapterDOI
The Schardinger dextrins.
TL;DR: The Schardinger dextrins are a group of homologous oligosaccharides, obtained from the breakdown of starch by the action of Bacillus macerans amylase, which has so far eluded attempts to bring it into well-defined crystalline form.