Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Build-up of an antimicrobial multilayer coating on a textile support based on a methylene blue-poly(cyclodextrin) complex.
Adeline Martin,Nicolas Tabary,Feng Chai,Laurent Leclercq,Jatupol Junthip,François Aubert-Viard,Christel Neut,Marek Weltrowski,Nicolas Blanchemain,Bernard Martel +9 more
TL;DR: In this article, an antibacterial multilayer coating activated with methylene blue (MB) and based on chitosan (CHT) and cyclodextrin polyelectrolyte (polyCD) was applied on a nonwoven polyethylene terephthalate (PET) textile support.
Journal ArticleDOI
Bilirubin adsorption properties of water-soluble adsorbents with different cyclodextrin cavities in plasma dialysis system
TL;DR: The use of α-, β- or γ-cyclodextrin (CD)-grafted polyethyleneimine (PEI) as water-soluble adsorbent as an effective agent for removing of bilirubin from plasma in dialysis system demonstrated the potential of β-CD-PEI.
Journal ArticleDOI
Nanocarriers and Microcarriers for Enhancing the UV Protection of Sunscreens: An Overview.
TL;DR: An up-to-date overview on the different nanocarrier systems that have been explored so far for encapsulating different types of UV filters present on the market, ranging from classical UV filters to new generation of UV actives.
Journal ArticleDOI
Enhanced dissolution and stability of lansoprazole by cyclodextrin inclusion complexation: preparation, characterization, and molecular modeling.
TL;DR: The dissolution rate and stability of LSP was dramatically enhanced by inclusion complexation regardless of CD type, and the enhanced photostability was due to the inclusion of the sulfinyl moiety into the HPCD cavity.
Journal ArticleDOI
Increased shelf‐life of fosphenytoin: Solubilization of a degradant, phenytoin, through complexation with (SBE)7m‐β‐CD
TL;DR: It was projected from the solubility of phenytoin and the kinetic information that fosphenytoin shelf lives as high as nine years at 25 degreesC and pH 7.4 in the presence of 60 mM of (SBE)7m-beta-CD might be possible while longer shelf lives may be possible at pH 8.0.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.