Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Incorporation of the sunscreen agent, octyl methoxycinnamate in a cellulosic fabric grafted with β-cyclodextrin
Santo Scalia,Rosanna Tursilli,Anna Bianchi,Pierandrea Lo Nostro,Eugenio Bocci,Francesca Ridi,Piero Baglioni +6 more
TL;DR: The in vitro sun protection factor of the textile support was markedly enhanced by impregnation with octyl methoxycinnamate of the beta-CDMCT grafted textile, which exhibits higher sunscreen agent retention and photoprotective properties than the unmodified textile material.
Journal ArticleDOI
Preparation and Characterisation of Natamycin: γ-Cyclodextrin Inclusion Complex and its Evaluation in Vaginal Mucoadhesive Formulations
TL;DR: The formation of complex between NT and gamma CyD and effective combination with polymers attain a bioadhesive and sustained release formulation of NT suitable for vaginal delivery and the effective treatment of Candida infections.
Journal ArticleDOI
Investigation of inclusion complex of cilnidipine with hydroxypropyl-β-cyclodextrin
TL;DR: The cilnidipine-HP-β-CD inclusion complex is identified as an effective new approach to design a novel formulation for pharmaceutical application.
Journal ArticleDOI
Recent advances and novel strategies in pre-clinical formulation development: an overview.
Amit K. Shah,Sunil A. Agnihotri +1 more
TL;DR: An overview of the significance of pre-formulation study parameters and their relevance to preclinical studies along with basic concepts and the recent studies conducted in the past decade are presented.
Journal ArticleDOI
The Periplasmic Cyclodextrin Binding Protein CymE from Klebsiella oxytoca and Its Role in Maltodextrin and Cyclodextrin Transport
TL;DR: Klebsiella oxytoca M5a1 has the capacity to transport and to metabolize alpha-, beta- and gamma-cyclodextrins and strains which gained this capacity by mutation could easily be selected, however.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.