Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
In Vivo Mechanisms of Intestinal Drug Absorption from Aprepitant Nanoformulations
Carl Roos,David Dahlgren,Staffan Berg,Jan Westergren,Bertil Abrahamsson,Christer Tannergren,Erik Sjögren,Hans Lennernäs +7 more
TL;DR: Increased numbers of nanoparticles and the presence of vesicles increased the rate of transport and availability of aprepitant in plasma and this effect can be attributed to an increased rate of mass transport through the aqueous boundary layer adjacent to the gut wall.
Journal ArticleDOI
Comparative studies of the influence of cyclodextrins on the stability of the sunscreen agent, 2-ethylhexyl-p-methoxycinnamate.
TL;DR: The complex of beta-CD with trans-EHMC enhances the chemical- and photo-stability of the sunscreen agent and limits adverse interactions of the UV filter with other formulation ingredients.
Journal ArticleDOI
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human african trypanosomiasis
Jean Rodgers,Amy J. Jones,Stéphane Gibaud,Barbara Bradley,Christopher McCabe,Michael P. Barrett,George Gettinby,Peter G. E. Kennedy +7 more
TL;DR: Two melarsoprol cyclodextrin inclusion complexes are investigated and found that these compounds retain trypanocidal properties in vitro and cure CNS-stage murine infections when delivered orally, once per day for 7-days, at a dosage of 0.05 mmol/kg.
Patent
Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
TL;DR: In this article, a method for the stereoselectively conversion of allylic ketones to the desired keto epoxides is described. But this method is not applicable to the preparation of amino acid keto-epoxides.
Journal ArticleDOI
Host-guest complexes of carotenoids with beta-glycyrrhizic acid.
TL;DR: The structure, stability, and reactivity of host-guest complexes between a set of carotenoids and the triterpene glycoside, beta-glycyrrhizic acid (GA), were investigated by different physicochemical techniques: highperformance liquid chromatography, optical absorption, and fluorescence spectroscopy as discussed by the authors.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.