Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
Reads0
Chats0
TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
More filters
Journal ArticleDOI
Nasal in situ gel containing hydroxy propyl β-cyclodextrin inclusion complex of artemether: development and in vitro evaluation
TL;DR: The formulation and evaluation of in situ gel for the nasal delivery of artemether (ARM), a poorly water-soluble antimalarial agent using temperature induced gelation technique using Pluronic with mucoadhesive polymer Hydroxy Propyl Methyl Cellulose (HPMC) K4M in different ratios showed the effective gelation, viscosity, gel strength and drug release properties.
Patent
Composition for enzyme inhibition
TL;DR: Compositions comprising one or more practically insoluble proteasome inhibitors and a cyclodextrin, particularly a substituted cyclodextrin, substantially increase the solubility of these protease inhibitors and facilitate their administration as mentioned in this paper.
Journal ArticleDOI
Water-soluble Complex of Curcumin with Cyclodextrins: Enhanced Physical Properties For Ocular Drug Delivery.
Doaa Nabih Maria,Doaa Nabih Maria,Sanjay R. Mishra,Lijia Wang,Abd ElGawad Helmy Abd-ElGawad,Osama A. Soliman,Marwa Salah El-Dahan,Monica M. Jablonski +7 more
TL;DR: F11 was formulated as eye drops, which provide a promising once daily novel topical delivery of this naturally derived phytochemical in retinitis pigmentosa.
Journal ArticleDOI
Effect of dimethyl‐β‐cyclodextrin concentrations on the pulmonary delivery of recombinant human growth hormone dry powder in rats
Monireh Jalalipour,Abdolhossien Rouholamini Najafabadi,Abdolhossien Rouholamini Najafabadi,Kambiz Gilani,Hadi Esmaily,Hosnieh Tajerzadeh +5 more
TL;DR: In conclusion, appropriate cyclodextrin concentration was achieved considering the protein aggregation and aerosol performance of the spray dried powders and the systemic absorption following administration through the rat lung.
References
More filters
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.