Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
A novel solid dosage form of rifampicin and isoniazid with improved functionality.
TL;DR: The problem of rifampicin degradation can be alleviated to a certain extent by this novel dosage form because of the minimization of physical contact between the 2 drugs and controlled release of rIFampic in acidic medium in the modified Rossett-Rice apparatus.
Journal ArticleDOI
Self-assembly Characterization of the β-Cyclodextrin and Hydrochlorothiazide System: NMR, Phase Solubility, ITC and QELS
Angelo Márcio Leite Denadai,Marcelo M. Santoro,L. H. M. da Silva,A.T. Viana,Robson A.S. Santos,Rubén D. Sinisterra +5 more
TL;DR: In this article, the authors characterized the short distance host-guest interactions by NMR techniques such as 1H chemical shift, longitudinal relaxation times, and thermodynamic solubility experiments.
Journal ArticleDOI
Preparation, characterization, and drug release properties of poly(2‐hydroxyethyl methacrylate) hydrogels having β‐cyclodextrin functionality
TL;DR: In this article, a new β-cyclodextrin urethane-methacrylate monomer was synthesized from the reaction of toluene-2,4-diisocyanate, 2-hydroxyethyl methcrylate (HEMA), and β-CD.
Journal ArticleDOI
Role of humic acid on oral drug delivery of an antiepileptic drug.
Mohd. Aamir Mirza,Suraj Prakash Agarwal,Md. Akhlaquer Rahman,Abdur Rauf,Niyaz Ahmad,Aftab Alam,Zeenat Iqbal +6 more
TL;DR: It could be concluded that HA may be tried as a complexing agent for antiepileptic drug and other classes of low water-soluble drug.
Journal ArticleDOI
Thermodynamics and structure of inclusion compounds of tauro- and glyco-conjugated bile salts and β-cyclodextrin
TL;DR: The interaction between natural beta-cyclodextrin and bile salts common in rat, dog and man was studied using isothermal titration calorimetry, and the structural differences in the interaction were investigated by (1)H-ROESY NMR and molecular modeling.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.