Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Studies of inclusion complexes of natural and modified cyclodextrin with (+)catechin by NMR and molecular modeling
Carolina Jullian,Sebastián Miranda,Gerald Zapata-Torres,Fernando Mendizabal,Claudio Olea-Azar +4 more
TL;DR: Analysis of the proton shift change using the continuous variation method confirm the formation of a 1:1 stoichiometric complex for catechin and the different CDs in aqueous medium and the detailed spatial configuration is proposed based on 2D NMR methods.
Journal ArticleDOI
Applications of cyclodextrins in medical textiles - review.
TL;DR: The kinetics, duration, diffusion flow and release media of the cyclodextrin drug for in vitro studies, as well as the release modeling of the active principle are presented.
Journal ArticleDOI
New Cyclodextrin Hydrogels Cross-Linked with Diglycidylethers with a High Drug Loading and Controlled Release Ability
Carmen Rodríguez-Tenreiro,Carmen Alvarez-Lorenzo,Ana I. Rodriguez-Perez,Angel Concheiro,Juan J. Torres-Labandeira +4 more
TL;DR: HPβCD hydrogels with good mechanical properties and tunable loading and release ability can be obtained by direct cross-linking with EGDE.
Journal ArticleDOI
Comparative evaluation of polymeric and amphiphilic cyclodextrin nanoparticles for effective camptothecin delivery.
TL;DR: Results indicated that CPT-loaded amphiphilic cyclodextrin nanoparticles might provide a promising carrier system for the effective delivery of this anticancer drug having bioavailability problems.
Journal ArticleDOI
Recent advances in technologies for vitamin A protection in foods
Simon M. Loveday,Harjinder Singh +1 more
TL;DR: Recent technological avenues for stabilizing vitamin A in foods are discussed, which are likely to improve nutritional efficacy and reduce the need for pharmaceutical supplementation.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.