Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
Reads0
Chats0
TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
More filters
Journal ArticleDOI
Bioadhesive properties and biodistribution of cyclodextrin-poly(anhydride) nanoparticles.
Maite Agüeros,Paloma Areses,Miguel Angel Campanero,Hesham H.A. Salman,Gemma Quincoces,Iván Peñuelas,Juan M. Irache +6 more
TL;DR: Overall, cyclodextrin-poly(anhydride) nanoparticles displayed homogeneous bioadhesive interactions within the gut, and the intensity of these interactions was higher than for control nanoparticles.
Journal ArticleDOI
Combined effect of cosolvent and cyclodextrin on solubilization of nonpolar drugs
TL;DR: A simple mathematical model has been developed to describe the combined effect of cosolvency and complexation on nonpolar drug solubilization that explains the decline in drug Solubility produced by low cosolvent concentrations as well as the increase in the solubilityproduced by high cosolent concentrations that are observed at all cyclodextrin concentrations.
Journal ArticleDOI
Antibacterial mechanism of artemisinin / beta-cyclodextrins against methicillin-resistant Staphylococcus aureus (MRSA).
TL;DR: The obtained results enable the potential use of ART/β-CDs-IC in the field of antimicrobial and indicated the membrane permeability of MRSA can be increased by the complexes.
Journal ArticleDOI
Thermosensitive mucoadhesive gel formulation loaded with 5-Fu: cyclodextrin complex for HPV-induced cervical cancer
TL;DR: Characterization of drug:CD complexes, thermosensitive gel formulations containing different mucoadhesive polymers and the drug in free or complexed form were characterized in vitro by determining the gelation temperature and the rheological behavior of different formulations along with the in vitro release profiles of these formulations in pH 5.5 citrate buffer.
Journal ArticleDOI
Production of advanced solid dispersions for enhanced bioavailability of itraconazole using KinetiSol® Dispersing
James DiNunzio,Justin R. Hughey,Chris Brough,Dave A. Miller,Robert O. Williams,James W. McGinity +5 more
TL;DR: Production of amorphous solid dispersions containing concentration-enhancing polymers through KinetiSol® Dispersing can provide improved oral bioavailability; however, additional formulation techniques must be developed to minimize variability associated with natural variations in subject gastrointestinal physiology.
References
More filters
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.