Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
New targets and delivery systems for antifungal therapy
Thomas J. Walsh,Maria Anna Viviani,E. Arathoon,C. Chiou,Mahmoud A. Ghannoum,Andreas H. Groll,Frank C. Odds +6 more
TL;DR: Development of new approaches for treatment of invasive fungal infections encompasses new delivery systems for approved and investigational compounds, as well as exploiting the cell membrane, cell wall and virulence factors as putative antifungal targets.
Journal ArticleDOI
Cyclodextrins as resveratrol carrier system
TL;DR: The formation of resveratrol–cyclodextrin inclusion complexes in aqueous solutions has been characterized using the hydroperoxidase activity of lipoxygenase as the enzymatic system using β- and G 2 -β-cyclodexin as the type of cyclodextrins used.
Journal ArticleDOI
Characterization of an inclusion complex of cholesterol and hydroxypropyl-β-cyclodextrin
TL;DR: An inclusion complex composed of cholesterol and hydroxypropyl-beta-cyclodextrin (HP betaCD) prepared by lyophilization was investigated and characterized and indicated that the formation of a cholesterol/HPbetaCD inclusion complex is more water soluble than cholesterol alone.
Journal ArticleDOI
Enhancement of solubility and bioavailability of β-lapachone using cyclodextrin inclusion complexes
Norased Nasongkla,Andy F. Wiedmann,Andrew J Bruening,Meghan Beman,Dale Ray,William Bornmann,David A. Boothman,Jinming Gao +7 more
TL;DR: Complexation of β-lap with HPβ-CD offers a major improvement in drug solubility and bioavailability as well as in vitro cytotoxicity and in vivo lethality studies with C57Blk/6 mice.
Journal ArticleDOI
Anhydrates and Hydrates of Olanzapine: Crystallization, Solid-State Characterization, and Structural Relationships
TL;DR: Olanzapine, a benzodiazepine agent used in the treatment of schizophrenia and related psychoses, crystallizes in 25+ crystal forms, seven of which are pharmaceutically relevant: I−III, three dihydrates (B, D, and E), and a higher hydrate as mentioned in this paper.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.