Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
β-cyclodextrin based dual-responsive multifunctional nanotheranostics for cancer cell targeting and dual drug delivery.
TL;DR: In vivo studies confirmed the nontoxicity and hemocompatibility of the nanoconjugates and site specific drug delivery due to folate conjugation and subsequent significant suppression in tumor growth was demonstrated by in vivo studies.
Journal ArticleDOI
Improvement in solubility and dissolution rate of 1,2‐dithiole‐3‐thiones upon complexation with β‐cyclodextrin and its hydroxypropyl and sulfobutyl ether‐7 derivatives
G. Dollo,Pascal Le Corre,Chollet Marylene,François Chevanne,Marcel Bertault,Jean-Louis Burgot,Roger Le Verge +6 more
TL;DR: The present study showed that complexation of 1,2-dithiole-3-thiones with beta-cyclodextrin derivatives resulted in an increase in solubility, allowing intravenous formulation for bioavailability and metabolism studies and an increase of the dissolution rate of the drugs, which should be of interest for oral absorption of these lipophilic compounds.
Journal ArticleDOI
Copper supported β-cyclodextrin functionalized PEGylated mesoporous silica nanoparticle -graphene oxide hybrid: An efficient and recyclable nano-catalyst for straightforward synthesis of 2-arylbenzimidazoles and 1,2,3-triazoles
TL;DR: In this paper, a PEG600 ended β-cyclodextrin functionalized PEGylated mesoporous silica nanoparticles-graphene oxide hybrid has been introduced as a heterogeneous support for immobilization of copper catalyst (denoted as Cu@βCD-PEG-mesoGO).
Journal ArticleDOI
Complex formation of Ibuprofen and β-Cyclodextrin by controlled particle deposition (CPD) using SC-CO2
TL;DR: In this paper, a controlled particle deposition (CPD) process was developed to dissolve the drug of interest in supercritical CO 2, followed by permeation of the supercritical solution into the pores of the carrier and precipitation of the drug inside the pores.
Journal ArticleDOI
Improvement on dissolution rate of inclusion complex of Rifabutin drug with β-cyclodextrin
TL;DR: The in vitro antimicrobial and antibiofilm activity of RFB sensible microorganisms was significantly increased by on inclusion complexation process, which is highly recognized as a successful and useful approach for the application in pharmaceutical field.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.