Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
Reads0
Chats0
TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
More filters
Journal ArticleDOI
Complexation induced aggregation and deaggregation of acridine orange with sulfobutylether-β-cyclodextrin.
TL;DR: The intriguing observation of sequential fluorescence switch off and switch on for an AOH+-SBE βCD system is clearly facilitated by the presence of butylether chains with SO3- end groups at the portals of SBEβCD, providing an additional ion-ion interaction and much enhanced hydrophobic interaction for cationic AOH+, compared to the native βCD host.
Journal ArticleDOI
Dyeing and antibacterial activation with methylene blue of a cyclodextrin modified polyester vascular graft
I. Kacem,T. Laurent,N. Blanchemain,N. Blanchemain,Christel Neut,Christel Neut,F. Chai,F. Chai,Stéphan Haulon,Stéphan Haulon,H. F. Hildebrand,H. F. Hildebrand,B. Martel +12 more
TL;DR: Kinetic and sorption isotherm studies showed that an impregnation of the polyCD modified prosthesis (PET-CD) in a 1 g L−1 of MB solution for 150 min was sufficient to reach the saturation of the device and the adsorption mechanism followed the Langmuir model.
Journal ArticleDOI
Formulations and toxicologic in vivo studies of aqueous cyclosporin A eye drops with cyclodextrin nanoparticles
Sunna Johannsdottir,Jóhannes Kári Kristinsson,Zoltán Fülöp,Gudrun Marta Asgrimsdottir,Einar Stefánsson,Thorsteinn Loftsson +5 more
TL;DR: The surfactant free aqueous 0.2% CyA eye drops did not cause ocular irritation or toxic side effects upon topical administration to rabbits once or twice a day for three months and were tested in vivo.
Journal ArticleDOI
Induction of Dendritic Cell Maturation and Activation by a Potential Adjuvant, 2-Hydroxypropyl-β-Cyclodextrin.
TL;DR: The data suggest that HP-β-CD induces phenotypic and functional maturation of DCs mainly mediated through lipid raft formation, which might mediate the adjuvanticity of HP- β-CD.
Journal ArticleDOI
Shear thinning/self-healing hydrogel based on natural polymers with secondary photocrosslinking for biomedical applications.
Esmat Jalalvandi,Amin Shavandi +1 more
TL;DR: The design and characterization of a shear thinning hydrogel that undergoes a disassembly when shear forces are applied during injection and is self-healing once the shearforces are removed is described.
References
More filters
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.