Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
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Journal ArticleDOI
Molecular buckets: cyclodextrins for oral cancer therapy.
Patricia Calleja,Judit Huarte,Maite Agüeros,Luisa Ruiz-Gatón,Socorro Espuelas,Juan M. Irache +5 more
TL;DR: This review focuses on the use of cyclodextrins alone or in combination with bioadhesive nanoparticles for oral delivery of drugs and the state-of-the-art technology and challenges in this area are discussed.
Journal ArticleDOI
Molecular Tailoring Approach for the Estimation of Intramolecular Hydrogen Bond Energy.
TL;DR: In this paper, the molecular tailoring approach (MTA) was used to estimate the intermolecular IHB energy in a system containing multiple H-bonds, which is a state-of-the-art method for estimating IHB energies.
Journal ArticleDOI
Danazol-β-cyclodextrin binary system: A potential application in emergency contraception by the oral route
TL;DR: The danazol-β-cyclodextrin binary system could serve as a new therapeutic application: an oral emergency contraceptive at a physiologically acceptable single dose.
Journal ArticleDOI
Host–guest system of 4-nerolidylcatechol in 2-hydroxypropyl-β-cyclodextrin: preparation, characterization and molecular modeling
Líllian Amélia Soares,Ana Flávia Vasconcelos Borges Leal,Leonardo Fernandes Fraceto,Elaine Rose Maia,Inês Sabioni Resck,Massuo J. Kato,Eric de Sousa Gil,Aparecido Ribeiro de Sousa,Luiz Carlos da Cunha,Kênnia Rocha Rezende +9 more
TL;DR: In this article, the interaction of 4-nerolidylcatechol (4-NRC), a potent antioxidant agent, and 2-hydroxypropyl-β-cyclodextrin (HP-β -CD) was investigated by the solubility method using Fourier transform infrared (FTIR) methods in addition to UV-Vis, 1H-nuclear magnetic resonance (NMR) spectroscopy and molecular modeling.
Patent
Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
TL;DR: In this paper, the present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same, and it is described in detail.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.