Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Light-Directed Self-Assembly of Robust Alginate Gels at Precise Locations in Microfluidic Channels
TL;DR: A remote-controlled fluidic valve that can be closed by shining light and reopened when the light is removed is demonstrated and it is shown that light-induced gelation of the authors' alginate fluid can be used to deposit biocompatible payloads at specific addresses within a microchannel.
Journal ArticleDOI
Interaction of artesunate with β-cyclodextrin: Characterization, thermodynamic parameters, molecular modeling, effect of PEG on complexation and antimalarial activity.
Renu Chadha,Sushma Gupta,Geeta Shukla,D. V. S. Jain,Raghuvir R. S. Pissurlenkar,Evans C. Coutinho +5 more
TL;DR: Solubility and dissolution profile of binary complex is enhanced in the presence of PEG, which is approximately at par with drug Me-β-CD complexes, as evident from elevation in the numerical value of the stability constant.
Journal ArticleDOI
β‐cyclodextrin reduces bioavailability of orally administered [3H]benzo[a]pyrene in the rat
Goran Westerberg,Lars Wiklund +1 more
TL;DR: The reduced systemic exposure of rats to radioactivity in the presence of beta-cyclodextrin is likely related to a reduced oral bioavailability.
Journal ArticleDOI
Characterization and in vitro evaluation of the formoterol/cyclodextrin complex for pulmonary administration by nebulization.
TL;DR: The aim of this work is to investigate the effect of cyclodextrin complexation on the pulmonary deposition of formoterol, a drug with a very poor aqueous solubility, after jet nebulization.
Journal ArticleDOI
Complexation induced fluorescence and acid–base properties of dapoxyl dye with γ-cyclodextrin: a drug-binding application using displacement assays
TL;DR: Host-guest complexation of dapoxyl sodium sulphonate (DSS), an intramolecular charge transfer dye with water-soluble and non-toxic macrocycle γ-cyclodextrin (γ-CD), has been investigated in a wide pH range and Steady-state absorption, fluorescence and time-resolved fluorescence measurements confirm the positioning of DSS into the hydrophobic cavity ofγ-CD.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.