Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Influence of hydroxypropyl-β-cyclodextrin on transdermal penetration and photostability of avobenzone
TL;DR: In vivo, inclusion of HPCD in sunscreen formulations may enhance photoprotection by reducing both skin penetration and photodecomposition of UV absorbers, as evidenced by the lowest extent of sunburn cell formation and edema induction.
Journal ArticleDOI
Dissolution behavior of β-cyclodextrin molecular inclusion complexes of aceclofenac
TL;DR: The dissolution of aceclofenac can be enhanced by the use of a hydrophilic carrier like β-CD, and molecular inclusion complexes with a 1:2 M ratio showed the maximum dissolution rate in comparison to other ratios.
Journal ArticleDOI
Sulfadiazine/hydroxypropyl-β-cyclodextrin host–guest system: Characterization, phase-solubility and molecular modeling
Márcia Valéria Gaspar de Araújo,Elze Kelly Barbosa Vieira,Gilderman Silva Lázaro,Leila S. Conegero,Luís Eduardo Almeida,Ledjane Silva Barreto,Nivan B. da Costa,Iara F. Gimenez +7 more
TL;DR: The inclusion mode involves a NH(2)-in orientation of the drug in the HPBCD cavity, according to the 2D NMR (ROESY) data and confirmed by molecular modeling using the semiempirical PM6 and RM1 methods.
Journal ArticleDOI
Effect of β-cyclodextrin complexation on solubility and enzymatic conversion of naringin.
TL;DR: Under the optimum conditions, the transforming rate of naringenin from naringin for inclusion complexes and free naring in was 98.7% and 56.2% respectively, suggesting that β-CD complexation can improve the aqueous solubility and consequently the enzymatic hydrolysis rate ofnaringin.
Journal ArticleDOI
Enhanced stability of a naringenin/2,6-dimethyl β-cyclodextrin inclusion complex: molecular dynamics and free energy calculations based on MM- and QM-PBSA/GBSA.
Waratchada Sangpheak,Wasinee Khuntawee,Peter Wolschann,Piamsook Pongsawasdi,Thanyada Rungrotmongkol +4 more
TL;DR: Van der Waals force played an important role as the key guest-host interaction for the complexation between naringenin and each cyclodextrin.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.