Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Effect of Cyclodextrin Complexation of Curcumin on its Solubility and Antiangiogenic and Anti-inflammatory Activity in Rat Colitis Model
TL;DR: The degree of colitis caused by administration of DSS was significantly attenuated by CD of curcumin, a nontoxic natural dietary product that could be useful in the therapeutic strategy for IBD patients.
Journal ArticleDOI
Natural product-based nanoformulations for cancer therapy: Opportunities and challenges
Dharambir Kashyap,Hardeep Singh Tuli,Mükerrem Betül Yerer,Ajay Sharma,Katrin Sak,Saumya Srivastava,Anjana Pandey,Vivek Garg,Gautam Sethi,Anupam Bishayee +9 more
TL;DR: The integration of phytotherapy and nanotechnology in the clinical setting may improve pharmacological response and better clinical outcome of patients.
Journal ArticleDOI
Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications.
TL;DR: The interest and the potential of Pickering emulsions for pharmaceutical applications are exposed and discussed, taking all the administration routes into consideration and focusing on organic particles.
Journal ArticleDOI
Optimizing saccharide-directed molecular delivery to biological receptors: design, synthesis, and biological evaluation of glycodendrimer-cyclodextrin conjugates.
Juan M. Benito,Marta Gómez-García,Carmen Ortiz Mellet,Isabelle Baussanne,Jacques Defaye,José M. García Fernández +5 more
TL;DR: The results confirm the high drug solubilization capability of this new type of betaCD-dendrimer construct and indicate that subtle changes in the architecture of the conjugate may have important consequences on receptor affinity.
Journal ArticleDOI
Operational calixarene-based fluorescent sensing systems for choline and acetylcholine and their application to enzymatic reactions
TL;DR: The described applications bypass problems related to the unselective binding of the macrocycle by coupling the signalling event with highly specific enzymatic transformations and the highly selective determination of absolute, low micromolar concentrations of both choline and acetylcholine by simple fluorescence measurements.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.