Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
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Journal ArticleDOI
Improvement in Solubility of Poorly Water Soluble Drug by Cogrinding with Highly Branched Cyclic Dextrin
TL;DR: In this article, the authors investigated the enhancement of the solubility of glibenclamide (GCM) by cogrinding it with highly branched cyclic dextrin (HBCD) using a ball mill.
Journal ArticleDOI
Regioselective Hydroxylation of Stilbenes by Engineered Cytochrome P450 from Thermobifida fusca YX
TL;DR: The cytochrome P450 monooxygenase 154E1 from Thermobifida fusca YX is identified which enables the synthesis of (E)-4,4′-dihydroxystilbene via direct double hydroxylation of (CYP154E1) and variants thereof accepted not only (E), but also possessed remarkable activity towards ortho- and meta-substituted hydroxystilbenes leading to resveratrol.
Journal ArticleDOI
Statistically designed enzymatic hydrolysis of an icariin/β-cyclodextrin inclusion complex optimized for production of icaritin
TL;DR: In this article, an icariin/β-cyclodextrin inclusion complex was used to generate icaritin, which increased the solubility by 17-fold.
Journal ArticleDOI
Bioactive ZnO Coatings Deposited by MAPLE-An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces.
Alexandra Elena Oprea,Loredana Mihaela Pandel,Ana-Maria Dumitrescu,Ecaterina Andronescu,Valentina Grumezescu,Mariana Carmen Chifiriuc,Laurenţiu Mogoantă,Tudor-Adrian Bălşeanu,George Dan Mogoşanu,Gabriel Socol,Alexandru Mihai Grumezescu,Florin Iordache,Horia Maniu,Mariana Chirea,Alina Maria Holban +14 more
TL;DR: In vitro and in vivo tests have revealed a good biocompatibility of ZnO/CD/Cfp coatings, which recommend them as competitive candidates for the development of antimicrobial surfaces with biomedical applications.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.