Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
Citations
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Journal ArticleDOI
Characteristics of Pyrene Phospholipid/γ-Cyclodextrin Complex
TL;DR: The present data provide strong evidence that the ability of gamma-CD to enhance intermembrane transfer of pyrene-labeled phospholipids is based on the formation of stoichiometric complexes in the aqueous phase, which should help in designing CD derivatives that are more efficient lipid carriers then those available at present.
Journal ArticleDOI
Increasing the stability of curcumin in serum with liposomes or hybrid drug-in-cyclodextrin-in-liposome systems: a comparative study.
Ahmed H. Matloob,Spyridon Mourtas,Pavlos G. Klepetsanis,Sophia G. Antimisiaris,Sophia G. Antimisiaris +4 more
TL;DR: Results demonstrate that HPβCD stabilizes CURC more than HPγCD, but liposome encapsulation provides substantially more protection, than CDs.
Journal ArticleDOI
Encapsulation in lipospheres of the complex between butyl methoxydibenzoylmethane and hydroxypropyl-beta-cyclodextrin.
TL;DR: Investigation of the incorporation into lipospheres of the complex between hydroxypropyl-beta-cyclodextrin and the sunscreen agent, butyl methoxydibenzoylmethane found that incorporation in lipid microparticles of BMDBM in the cyclodesxtrin complex form is more effective in enhancing the sunscreen photostability than the complex alone or the liposphere-entrapped free BM DBM.
Journal ArticleDOI
Molecular Electrostatic Potentials and Hydrogen Bonding in α-, β-, and γ-Cyclodextrins
TL;DR: In this paper, the electronic structure and the molecular electrostatic potentials in α-, β-, and γ-CDs were derived using the hybrid density functional theory employing the three-parameter exchange correlation functional due to Becke, Lee, Yang, and Parr.
Patent
Compounds for proteasome enzyme inhibition
Mark S. Smyth,Guy J. Laidig +1 more
TL;DR: In this paper, the peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.