Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Evaluation of cyclodextrin solubilization of drugs
TL;DR: The most common stoichiometric determination during formulation studies is 1:1, i.e. one drug molecule forms a complex with one cyclodextrin molecule, and the apparent stability constant (K1:1) of the 1:2 drug/cyclodextrins complexes calculated by the phase-solubility method is found.
Journal ArticleDOI
Cyclodextrin-based polymeric materials: synthesis, properties, and pharmaceutical/biomedical applications.
TL;DR: This review describes the synthesis, properties, and, in particular, biomedical and pharmaceutical applications of an upcoming class of polymeric networks and assemblies based on cyclodextrins (CDs).
Journal ArticleDOI
Highly soluble cyclodextrin derivatives: chemistry, properties, and trends in development.
Lajos Szente,Jozsef Szejtli +1 more
TL;DR: Literary data taken from Cyclolab's databank support the validity of statements in evaluation of trends of development of CD derivatives as pharmaceutical excipients.
Journal ArticleDOI
Approaches for Enhancing Oral Bioavailability of Peptides and Proteins
TL;DR: The physiological barriers to oral delivery of peptides and proteins and novel pharmaceutical approaches to circumvent these barriers and enhance oral bioavailability of these macromolecules are summarized.
Journal ArticleDOI
The utility of cyclodextrins for enhancing oral bioavailability.
Lee A. Miller,Imran Ahmed +1 more
TL;DR: The mechanisms by which cyclodextrins influence key drug delivery processes, again emphasizing solubilization capabilities, are discussed to provide further insight into why cyclodeXTrins will increase bioavailability in certain cases but not influence or possibly decrease bio availability in others.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.