Journal ArticleDOI
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
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TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1996-10-01. It has received 2124 citations till now. The article focuses on the topics: Cyclodextrin & Inclusion compound.read more
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Journal ArticleDOI
Efficacy of clofazimine–modified cyclodextrin against Mycobacterium avium complex in human macrophages
TL;DR: The activity of this novel modified clofazimine-cyclodextrin complex against Mycobacterium avium complex in human macrophages is examined, and its cytotoxicity is evaluated.
Journal ArticleDOI
Liquid formulation of a novel non-fluorinated topical quinolone, T-3912, utilizing the synergic solubilizing effect of the combined use of magnesium ions and hydroxypropyl-β-cyclodextrin
TL;DR: This combined system of Mg(2+) ions, HPbetaCD and PVP has potential as a liquid formulation of T-3912 for topical application, especially for opthalmic use.
Journal ArticleDOI
Hydrolysis of Fish Oil by Lipases Immobilized Inside Porous Supports
Gloria Fernández-Lorente,Carolina Pizarro,Dolores Lopez-Vela,Lorena Betancor,Alfonso V. Carrascosa,Benevides C. C. Pessela,Jose M. Guisan +6 more
TL;DR: A new assay was designed to measure the release of omega-3 acids from the hydrolysis of sardine oil by lipases immobilized inside porous supports and three different lipases adsorbed on octyl-Sepharose were compared: Candida antarctica lipase-fraction B, Thermomyces lanuginosa lipase (TLL) and RML.
Journal ArticleDOI
Synthesis and spectral investigation of Al(III) catechin/β-cyclodextrin and Al(III) quercetin/β-cyclodextrin inclusion compounds
TL;DR: Al-catechin/beta-cyclodextrin and Al-quercetin/β-cyclodesxtrin (beta-CD) inclusion compounds were synthesized and characterized by IR, UV-vis, 1H and 13C NMR and TG and DTA analyses.
Journal ArticleDOI
Effect of drug physicochemical properties on in vitro characteristics of amphiphilic cyclodextrin nanospheres and nanocapsules
TL;DR: Drug properties are significant for the formulation of nanocapsules and nanospheres and could be achieved by selecting the appropriate drug delivery system and the optimum drug.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Book
Handbook of Pharmaceutical Excipients
TL;DR: The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and safety.
Journal ArticleDOI
Cyclodextrin Inclusion Compounds in Research and Industry
TL;DR: As cyclodextrins catalyze several chemical reactions they and their functionalized derivatives provide useful enzyme models and can be used to advantage in the production of pharmaceuticals, pesticides, foodstuffs, and toilet articles.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Book
Cyclodextrins in Pharmacy
TL;DR: The present study focused on the development and application of Cyclodextrin Inclusion Compounds in Various Drug Formulations, as well as their applications in Pharmaceutical Applications and Legal Aspects.